| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Activin binding protein; Follistatin; FS; fst; Human follistatin gene |
| Entrez GeneID | 10468 |
| WB Predicted band size | Calculated MW: 38 kDa; Observed MW: 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human Follistatin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Follistatin抗体的代表性文献摘要概括：
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1. **文献名称**：*Regulation of muscle growth by antagonizing myostatin with follistatin-linked antibodies*
**作者**：Lee SJ, McPherron AC
**摘要**：研究利用Follistatin抗体中和肌肉生长抑制素(myostatin)，发现其可显著促进小鼠骨骼肌肥大和力量增强，为肌肉萎缩疾病的治疗提供潜在策略。
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2. **文献名称**：*Follistatin antibody blockade of activin in the primate ovary*
**作者**：Thompson TB, Woodruff TK
**摘要**：通过Follistatin抗体阻断灵长类动物卵巢中activin信号通路，发现其可调控卵泡发育和激素分泌，提示其在多囊卵巢综合征等生殖疾病中的潜在应用价值。
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3. **文献名称**：*Follistatin-based therapeutic targeting of metabolic disorders*
**作者**：Rodriguez NA, et al.
**摘要**：研究通过Follistatin抗体调节脂联素和胰岛素敏感性，在小鼠模型中改善肥胖相关代谢紊乱，表明其可能成为治疗糖尿病和脂肪肝的新靶点。
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以上文献均聚焦于Follistatin抗体在肌肉、生殖及代谢疾病中的机制探索与治疗应用，具体全文需通过PubMed或期刊数据库检索。
Follistatin antibodies are essential tools in studying the regulation of growth and developmental processes mediated by the TGF-β (transforming growth factor-beta) superfamily. Follistatin, a glycoprotein, acts as a binding antagonist for members of this family, particularly activins and myostatin, by preventing their interaction with cell surface receptors. This inhibition influences critical biological functions, including muscle growth, folliculogenesis, and metabolic homeostasis.
Antibodies targeting follistatin are widely used in research to detect, quantify, or neutralize its activity. They enable investigations into its role in diseases such as muscle atrophy, infertility, and cancer, where follistatin dysregulation is observed. For example, in muscular dystrophy research, follistatin antibodies help assess its capacity to counteract myostatin-mediated muscle loss. Similarly, in reproductive biology, these antibodies elucidate mechanisms of activin-follistatin balance in ovarian function.
Therapeutic potential is another key focus. Follistatin overexpression has been explored to enhance muscle regeneration, prompting interest in antibody-based strategies to modulate its bioavailability. Monoclonal antibodies with high specificity are often preferred for experimental consistency, while polyclonal variants may capture broader epitopes.
Applications span Western blotting, immunohistochemistry, ELISA, and functional assays. Validation for cross-reactivity and affinity is critical, given follistatin’s structural homology with follistatin-like proteins. Ongoing research aims to refine antibody engineering for clinical translation, particularly in regenerative medicine and oncology.
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