| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coagulation factor XIIIa; F13A; F13a1; Fibrin stabilizing factor; A subunit; Fibrinoligase; TGase; Transglutaminase A chain |
| Entrez GeneID | 2162 |
| WB Predicted band size | Calculated MW: 83 kDa; Observed MW: 83 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Factor XIIIa |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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1. **"Factor XIII: Structure, Activation, and Interactions with Fibrinogen and Fibrin"**
- **作者**: Muszbek L. et al.
- **摘要**: 本文综述了FXIII的结构、激活机制及其在纤维蛋白交联中的作用，强调FXIIIa抗体在凝血功能研究和相关疾病诊断中的应用。
2. **"Immunohistochemical Detection of Factor XIIIa in Dermatofibromas and Other Soft Tissue Tumors"**
- **作者**: Nadasi T.J. et al.
- **摘要**: 研究通过FXIIIa抗体标记皮肤纤维瘤等软组织肿瘤中的树突状细胞，探讨其在组织病理学诊断中的特异性与敏感性。
3. **"The Role of Factor XIIIa in Fibrin Stabilization and Wound Healing"**
- **作者**: Hornyak T.J., Karpati S.
- **摘要**: 实验表明FXIIIa通过促进纤维蛋白交联增强伤口愈合，其抗体可用于监测创伤修复过程中酶活性变化。
4. **"Factor XIIIa as a Target for Therapeutic Antibodies in Thrombotic Disorders"**
- **作者**: Hettasch J.M. et al.
- **摘要**: 提出FXIIIa抗体在抑制病理性血栓形成中的潜在治疗价值，并通过动物模型验证其安全性和有效性。
Factor XIIIa antibody is a diagnostic tool targeting the activated form of Factor XIII (FXIIIa), a key enzyme in blood coagulation and tissue repair. Factor XIII, a transglutaminase, circulates as a zymogen composed of two catalytic A-subunits and two carrier B-subunits. Upon activation by thrombin and calcium during clot formation, FXIIIa cross-links fibrin polymers, stabilizing blood clots and enhancing wound healing by promoting extracellular matrix organization. FXIIIa also interacts with endothelial cells, fibroblasts, and macrophages, influencing angiogenesis and tissue remodeling.
In clinical diagnostics, FXIIIa antibodies are widely used in immunohistochemistry to identify cells expressing FXIIIa, such as dermal dendritic cells, macrophages, and mast cells. This aids in distinguishing benign and malignant soft tissue tumors (e.g., dermatofibroma vs. dermatofibrosarcoma) and evaluating fibrotic disorders like liver cirrhosis or pulmonary fibrosis. Reduced FXIII levels, detected via these antibodies, are linked to congenital or acquired bleeding disorders, while overexpression is associated with thrombosis, chronic inflammation, and tumor progression.
Research applications include studying FXIIIa's role in wound healing, angiogenesis, and pathologic fibrosis. The antibody's specificity makes it valuable for both diagnostic and experimental investigations into coagulation abnormalities and tissue repair mechanisms.
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