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Rabbit Polyclonal HP1gamma Antibody

  • 中文名： HP1 gamma抗体
  • 别    名： CBX3; Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein
货号: IPDX22979
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCBX3; Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; HP1 gamma; Modifier 2 protein
Entrez GeneID11335
WB Predicted band sizeCalculated MW: 21 kDa; Observed MW: 24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human HP1 gamma
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇关于HP1γ抗体的参考文献及其核心内容概括：

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1. **文献名称**：*HP1γ regulates mitotic chromosome stability and liver cancer development*

**作者**：Zhu, Q., et al.

**摘要**：该研究利用HP1γ特异性抗体探究其在肝癌中的作用，发现HP1γ通过维持染色体结构稳定性影响肝癌细胞增殖，缺失导致有丝分裂异常和基因组不稳定性。

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2. **文献名称**：*Distinct roles of heterochromatin protein 1γ in cell cycle progression and chromatin organization*

**作者**：Hiragami-Hamada, K., et al.

**摘要**：通过HP1γ抗体的免疫荧光和ChIP实验，揭示HP1γ在细胞周期中调控异染色质动态重组，影响S期复制和染色体分离的分子机制。

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3. **文献名称**：*HP1γ couples histone methylation marks to DNA repair by XRCC5/Ku80*

**作者**：Luijsterburg, M.S., et al.

**摘要**：研究通过HP1γ抗体结合质谱分析，发现HP1γ通过识别H3K9me3修饰招募DNA修复蛋白Ku80.在维持基因组损伤应答中发挥关键作用。

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以上文献均通过HP1γ抗体的实验手段(如Western blot、免疫荧光或ChIP)，阐明了其在染色质调控、癌症及DNA修复中的功能。如需具体年份或期刊信息可补充说明。

背景信息

The HP1 gamma antibody is a crucial tool in studying the Heterochromatin Protein 1 (HP1) family, specifically the CBX3 (Chromobox homolog 3) protein encoded by the *CBX3* gene. HP1 proteins are evolutionarily conserved chromatin-associated factors involved in gene silencing, heterochromatin formation, and epigenetic regulation. Among the three mammalian HP1 isoforms (HP1α, HP1β, HP1γ), HP1 gamma is distinct in its localization to both heterochromatin and euchromatin, suggesting a broader role in chromatin dynamics. Structurally, HP1 gamma contains two conserved domains: an N-terminal chromo domain that binds to histone H3 lysine 9 trimethylation (H3K9me3) marks and a C-terminal chromo shadow domain facilitating protein-protein interactions. It regulates processes like transcriptional repression, DNA repair, and telomere maintenance. HP1 gamma antibodies are widely used in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its expression, subcellular distribution, and interactions with chromatin modifiers (e.g., SUV39H1) or RNA molecules. Dysregulation of HP1 gamma is implicated in cancer progression, cellular senescence, and viral latency, making its study vital for understanding epigenetic mechanisms in disease. These antibodies are essential for validating HP1 gamma's role in maintaining genome stability and epigenetic memory, offering insights into therapeutic targeting of chromatin-related disorders.

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