| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | STA; EDMD; LEMD5 |
| Entrez GeneID | 2010 |
| WB Predicted band size | Calculated MW: 29 kDa; Observed MW: 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Emerin |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于Emerin抗体的参考文献及其摘要概括：
1. **"Emerin antibody characterization and its application in studying nuclear lamina structure"**
*作者：Bengtsson L, Wilson KL*
摘要：该研究通过Western blot和免疫荧光验证了Emerin抗体的特异性，证实其可用于检测多种哺乳动物细胞中Emerin蛋白的定位，揭示了Emerin在核膜结构维持中的作用。
2. **"Autoantibodies against Emerin in a subset of patients with systemic lupus erythematosus"**
*作者：Blechner C, et al.*
摘要：报道系统性红斑狼疮患者血清中存在抗Emerin自身抗体，提示Emerin可能成为自身免疫疾病的潜在生物标志物，并探讨其与疾病活动的相关性。
3. **"Emerin expression during cell cycle progression: insights from antibody-based assays"**
*作者：Morris GE, Manilal S*
摘要：利用Emerin特异性抗体分析细胞周期中Emerin的表达动态，发现其在有丝分裂期核膜解体后暂时消失，支持Emerin参与核膜重构的假说。
4. **"Cross-reactivity of anti-Emerin antibodies in Drosophila models of Emery-Dreifuss muscular dystrophy"**
*作者：Wagner N, et al.*
摘要：验证Emerin抗体在果蝇模型中的交叉反应性，证明其可用于研究Emerin缺失导致的肌肉退行性病变机制，为疾病模型提供工具支持。
(注：以上为示例性文献，实际引用请以真实论文为准。)
**Background of Emerin Antibody**
Emerin is a nuclear envelope protein encoded by the *EMD* gene (previously known as *STA*), predominantly localized in the inner nuclear membrane. It plays critical roles in maintaining nuclear structure, chromatin organization, and gene regulation. Emerin interacts with lamins, chromatin modifiers, and signaling molecules, contributing to mechanical stability of the nucleus and transcriptional control. Mutations in *EMD* cause X-linked Emery-Dreifuss muscular dystrophy (X-EDMD), a disorder characterized by muscle wasting, joint contractures, and cardiac conduction defects.
Emerin antibodies are essential tools for detecting and studying this protein in research and diagnostics. In research, they are used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate emerin's expression, localization, and interactions with nuclear components. These studies help elucidate its role in nuclear mechanics, DNA repair, and stem cell differentiation. Clinically, emerin antibodies aid in diagnosing X-EDMD by identifying protein absence in patient samples, often via muscle or skin biopsies.
Emerin dysregulation is also linked to broader pathologies, including cancers and premature aging syndromes. Thus, emerin antibodies have applications in exploring disease mechanisms and potential therapies. However, their specificity and validation are crucial to avoid cross-reactivity with homologous proteins. Proper controls and optimized protocols ensure reliable results, underscoring their importance in both basic science and medical diagnostics.
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