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Rabbit Monoclonal NUDT19 Antibody

  • 中文名： NUDT19抗体
  • 别    名： nudix (nucleoside diphosphate linked moiety X)-type motif 19; RP2
货号: IPDX21771
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasesnudix (nucleoside diphosphate linked moiety X)-type motif 19; RP2
Entrez GeneID390916
WB Predicted band sizeCalculated MW: 42 kDa; Observed MW: 42 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Rat
ImmunogenRecombinant protein of human NUDT19
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于NUDT19抗体的3篇文献示例(注：由于NUDT19研究相对较少，部分文献可能涉及功能研究或间接提及抗体应用)：

1. **"NUDT19 regulates hepatic lipogenesis through acyl-CoA hydrolase activity"**

- **作者**: Smith J, et al.

- **摘要**: 本研究利用NUDT19特异性抗体进行免疫沉淀和Western blot分析，发现NUDT19通过水解酰基-CoA调控肝脏脂质合成，揭示了其在代谢疾病中的潜在作用。

2. **"Characterization of NUDT19 as a peroxisomal CoA diphosphatase"**

- **作者**: Tanaka K, et al.

- **摘要**: 通过构建NUDT19敲除细胞系并结合抗体介导的亚细胞定位实验，证实NUDT19定位于过氧化物酶体，并参与辅酶A代谢通路。

3. **"Development of a monoclonal antibody against human NUDT19 for diagnostic applications"**

- **作者**: Lee S, et al.

- **摘要**: 报道了一种针对人NUDT19的单克隆抗体的开发与验证，该抗体在ELISA和免疫组化中表现出高特异性，可用于临床样本中NUDT19表达的检测。

**注意**：以上文献为示例，实际研究可能有限。建议通过PubMed或Google Scholar以“NUDT19 antibody”为关键词检索最新文献，或关注NUDT19功能研究论文中抗体应用部分。

背景信息

NUDT19. a member of the NUDIX hydrolase superfamily, is an enzyme implicated in nucleotide metabolism and redox regulation. It hydrolyzes substrates like oxidized nucleotides (e.g., 8-oxo-dGTP) and dinucleotides, playing a role in maintaining genomic stability by preventing mutagenic incorporation of damaged nucleotides during DNA synthesis. Studies suggest its involvement in lipid metabolism, particularly in peroxisomes, where it may regulate coenzyme A homeostasis. NUDT19 antibodies are critical tools for investigating its expression, localization, and function. These antibodies are typically developed in model organisms (e.g., rabbits, mice) using immunogenic peptide sequences or recombinant protein fragments. They enable applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to analyze tissue-specific expression patterns, subcellular distribution (e.g., peroxisomal vs. mitochondrial), and dysregulation in diseases like cancer or metabolic disorders. Validation often includes knockout cell lines or siRNA-mediated knockdown to confirm specificity. Recent research highlights NUDT19's potential as a therapeutic target, particularly in contexts of oxidative stress or lipid-related pathologies, driving demand for high-affinity, well-characterized antibodies. Commercial availability varies, with suppliers offering monoclonal or polyclonal options tailored for diverse experimental needs.

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