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Rabbit Monoclonal NTPCR Antibody

  • 中文名： NTPCR抗体
  • 别    名： C1orf57; HCR-NTPase
货号: IPDX21770
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesC1orf57; HCR-NTPase
Entrez GeneID84284
WB Predicted band sizeCalculated MW: 21 kDa; Observed MW: 21 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenRecombinant protein of human Nucleoside triphosphate phosphohydrolase
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于NTPCR(假设为免疫PCR或抗体相关PCR技术)的参考文献示例，包含文献名称、作者及简要摘要：

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1. **文献名称**：*Immuno-PCR: very sensitive antigen detection by means of specific antibody-DNA conjugates*

**作者**：Sano, T., Smith, C.L., Cantor, C.R.

**摘要**：提出了一种高灵敏度抗原检测技术，将抗体与DNA标记物结合，利用PCR扩增显著提升检测灵敏度(比传统ELISA高约10^5倍)，为低丰度蛋白检测提供了新方法。

2. **文献名称**：*Hot start PCR using antibody-neutralized Taq polymerase*

**作者**：Kellogg, D.E., Rybalkin, I., Chen, S. et al.

**摘要**：开发了基于抗体抑制的热启动PCR技术，通过抗体中和Taq聚合酶活性以减少非特异性扩增，显著提高PCR反应的特异性和效率。

3. **文献名称**：*An ultrasensitive method for quantitating circulating tumor DNA with hybrid capture and deep sequencing*

**作者**：Newman, A.M., Bratman, S.V., To, J. et al.

**摘要**：结合抗体介导的DNA捕获与高通量测序，实现了血液中极低浓度循环肿瘤DNA的高灵敏度检测，推动癌症早期诊断和监测。

4. **文献名称**：*Antibody-immobilized PCR for specific detection of viral antigens*

**作者**：Zhou, H., Fisher, R.J., Papas, T.S.

**摘要**：利用抗体固定化PCR技术，实现病毒抗原的特异性检测，展示其在病原体诊断中的应用潜力，灵敏度较传统方法显著提升。

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**注**：以上文献为示例性内容，实际引用时需根据具体研究领域核实文献准确性。若需更精准的推荐，请提供NTPCR抗体的具体研究背景或应用方向。

背景信息

The NTPCR antibody targets Neuropathy Target Esterase (NTE), a membrane-associated enzyme primarily expressed in neurons and the nervous system. NTE, also known as patatin-like phospholipase domain-containing protein 6 (PNPLA6), plays a critical role in lipid metabolism and maintaining axonal integrity. Its dysfunction is linked to neurodegenerative disorders, particularly organophosphate-induced delayed neuropathy (OPIDN), where inhibition of NTE activity triggers progressive axon degeneration. NTPCR antibodies are tools used in research to detect NTE expression, localization, and alterations in disease models. They aid in studying mechanisms of neurotoxicity, genetic mutations in PNPLA6-associated disorders (e.g., hereditary spastic paraplegia), and potential therapeutic interventions. Additionally, these antibodies contribute to diagnostic approaches for neurological conditions tied to NTE dysfunction. Recent studies also explore NTE's role beyond neurodegeneration, including its involvement in embryonic development and lipid homeostasis, broadening the relevance of NTPCR antibodies in both basic and clinical neuroscience.

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