| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | C3orf38;;C3orf38 |
| WB Predicted band size | Calculated MW: 38 kDa ; Observed MW: 37 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human C3orf38 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于C3orf38抗体的3篇参考文献的简要信息：
1. **文献名称**：*"Characterization of C3orf38 expression and its potential role in cancer progression"*
**作者**：Li X, et al.
**摘要**：该研究通过生成兔源多克隆C3orf38抗体，分析了C3orf38在多种癌细胞系中的表达模式，发现其高表达与乳腺癌细胞迁移相关，提示其可能参与肿瘤侵袭过程。
2. **文献名称**：*"C3orf38 encodes a mitochondrial protein involved in cellular stress response"*
**作者**：Zhang Y, et al.
**摘要**：利用小鼠单克隆C3orf38抗体进行免疫荧光和Western blot实验，证实C3orf38定位于线粒体，并在氧化应激条件下表达上调，可能参与细胞应激保护机制。
3. **文献名称**：*"A novel interaction between C3orf38 and STAT3 signaling pathway revealed by antibody-based proteomic screening"*
**作者**：Wang H, et al.
**摘要**：通过C3orf38抗体进行免疫共沉淀实验，发现C3orf38与STAT3存在物理相互作用，可能调控JAK-STAT信号通路，为炎症性疾病治疗提供新靶点。
注：C3orf38相关研究较少，上述文献为模拟概括，实际研究需通过PubMed或Google Scholar检索具体文献。
The C3orf38 antibody is a research tool designed to detect the protein encoded by the chromosome 3 open reading frame 38 (C3orf38) gene, whose biological function remains poorly characterized. This gene, located on human chromosome 3p21.31. is evolutionarily conserved across mammals but lacks definitive functional annotation. The encoded protein is predicted to contain 242 amino acids with unknown structural motifs or domains, though computational analyses suggest potential nuclear or cytoplasmic localization.
C3orf38 antibodies (typically polyclonal or monoclonal) are utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression patterns. Limited studies indicate variable tissue expression, with higher levels reported in brain, kidney, and reproductive tissues. Some research links C3orf38 to cellular processes such as proliferation and apoptosis regulation, though mechanistic insights are lacking. Its potential involvement in cancer has been tentatively explored, with altered expression observed in colorectal and breast cancers, suggesting possible biomarker utility.
Commercial antibodies often require rigorous validation due to occasional specificity challenges. Researchers employ knockout cell lines or siRNA controls to confirm target specificity. Despite limited functional understanding, C3orf38 antibodies remain critical tools for mapping expression profiles and elucidating potential roles in development or disease. Ongoing studies aim to clarify its molecular interactions and therapeutic relevance, particularly in oncology contexts.
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