Rabbit Monoclonal MRPS31 Antibody

The MRPS31 antibody is a research tool designed to detect and study the mitochondrial ribosomal protein S31 (MRPS31), a component of the 28S subunit within the mitochondrial ribosome. As part of the mitochondrial small ribosomal subunit, MRPS31 plays a critical role in mitochondrial protein synthesis, which is essential for oxidative phosphorylation (OXPHOS) and cellular energy production. Mitochondrial ribosomes are distinct from their cytoplasmic counterparts, reflecting evolutionary divergence and specialization in translating mitochondrially encoded mRNA. MRPS31 is nuclear-encoded and imported into mitochondria, where it contributes to ribosome assembly and stability. Dysregulation of mitochondrial ribosomal proteins, including MRPS31. has been linked to mitochondrial disorders, metabolic diseases, and cancer, emphasizing its biological relevance. Researchers utilize MRPS31 antibodies in techniques like Western blotting, immunofluorescence, or immunohistochemistry to explore its expression patterns, subcellular localization, and interactions in normal and diseased states. Studies have also investigated its role in apoptosis, cellular stress responses, and potential as a biomarker in certain cancers. Validation of MRPS31 antibodies typically involves testing specificity using knockout controls or siRNA-mediated knockdown. This antibody serves as a key reagent for advancing understanding of mitochondrial biology and its implications in human health and disease.