| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | gz-alpha |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GNAZ |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CEP43抗体的模拟参考文献示例(请注意，以下内容为示例，实际文献需通过学术数据库验证)：
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1. **"CEP43 regulates centriole duplication and ciliogenesis in vertebrate cells"**
*Smith A, et al. (2018). Journal of Cell Science.*
摘要：本研究开发了一种针对CEP43的多克隆抗体，证实其在中心体复制中的关键作用。抗体通过免疫荧光验证了CEP43在纤毛基部的定位，并发现其缺失导致纤毛形成障碍。
2. **"Characterization of a novel monoclonal antibody against CEP43 for cancer biomarker studies"**
*Zhang L, et al. (2020). Scientific Reports.*
摘要：报道一种高特异性小鼠单克隆CEP43抗体的制备，用于检测多种癌细胞系中CEP43的异常表达，提示其与肿瘤增殖和转移的相关性。
3. **"Functional analysis of CEP43 in centrosome amplification using CRISPR and antibody-based approaches"**
*Lee H, et al. (2019). Molecular Biology of the Cell.*
摘要：结合CRISPR敲除和CEP43抗体免疫印迹，揭示CEP43在维持中心体数目稳定性中的作用，抗体验证了其在G1/S期调控中的动态变化。
4. **"Structural insights into CEP43 interactions through epitope mapping of custom antibodies"**
*Brown K, et al. (2021). Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics.*
摘要：通过抗原表位定位分析兔源CEP43抗体的结合区域，探讨CEP43与邻近中心体蛋白的相互作用网络，为结构研究提供工具。
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**提示**：以上为模拟内容，实际文献请通过PubMed、Google Scholar等平台以关键词“CEP43 antibody”或“CEP43 + centriole”检索，并优先选择近5年、高被引的原始研究或权威综述。
The CEP43 antibody is a research tool designed to detect and study the centrosomal protein 43 (CEP43), a component of the centrosome, a critical organelle involved in cell division, microtubule organization, and maintenance of genomic stability. CEP43 is implicated in regulating centrosome structure and function, particularly during mitosis and ciliogenesis. Dysregulation of centrosomal proteins like CEP43 has been linked to mitotic errors, chromosomal instability, and diseases such as cancer or ciliopathies.
This antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to localize CEP43 within cells, assess its expression levels, or investigate its interaction partners. Researchers utilize it to explore CEP43's role in cell cycle progression, centrosome duplication, and cilia formation, as well as its potential involvement in pathological conditions.
CEP43 antibodies are typically produced in hosts such as rabbits or mice using immunogenic peptides derived from conserved regions of the human CEP43 protein. Specificity is validated through knockout controls or siRNA-mediated depletion. High-quality CEP43 antibodies enable precise analysis of protein dynamics, aiding studies on cellular division mechanisms, developmental biology, and disease pathways associated with centrosomal dysfunction.
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