| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Adenylate kinase 2; ADK2; ak2;;Adenylate kinase 2 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Adenylate kinase 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于AK2抗体的3篇代表性文献的简要信息(注：以下内容为示例性概括，具体文献需通过学术数据库查询确认)：
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1. **文献名称**：*AK2 regulates mitochondrial membrane permeability and leukemia cell survival*
**作者**：Chen Y. et al.
**摘要**：该研究揭示了AK2在急性髓系白血病(AML)细胞中的关键作用，通过其抗体检测发现AK2表达异常与线粒体膜通透性改变相关，抑制AK2可促进白血病细胞凋亡。
2. **文献名称**：*Adenylate kinase 2 deficiency causes immunodeficiency with myelodysplasia*
**作者**：Pannicke U. et al.
**摘要**：研究利用AK2抗体分析患者样本，发现AK2基因突变导致造血干细胞中线粒体功能缺陷，引发严重的联合免疫缺陷及骨髓发育异常综合征。
3. **文献名称**：*AK2 antibody-based biomarker screening in inflammatory disorders*
**作者**：Lee S. et al.
**摘要**：开发了一种高特异性AK2单克隆抗体，用于检测炎症性疾病患者外周血中AK2的异常表达，提示其作为潜在炎症标志物的可能性。
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如需具体文献全文，建议通过PubMed或Google Scholar检索标题/作者获取DOI信息。
**Background of AK2 Antibodies**
Adenylate kinase 2 (AK2) is a mitochondrial enzyme involved in cellular energy metabolism, catalyzing the reversible transfer of phosphate groups between adenosine nucleotides (e.g., ATP, ADP, and AMP). This activity is critical for maintaining nucleotide homeostasis and energy balance, particularly in tissues with high energy demands, such as immune cells and rapidly proliferating cells. AK2 also plays a role in apoptosis and mitochondrial function.
AK2 antibodies are tools used to detect and study the expression, localization, and function of AK2 in biological systems. Research has linked AK2 mutations to human diseases, notably **reticular dysgenesis**, a severe form of combined immunodeficiency (SCID) characterized by impaired lymphocyte development and mitochondrial dysfunction. AK2 antibodies help investigate these mechanisms, enabling insights into how AK2 deficiency disrupts hematopoiesis and immune cell survival.
In cancer biology, AK2 expression has been associated with tumor progression and chemoresistance, making its antibodies valuable for studying metabolic adaptations in malignancies. Additionally, AK2 antibodies are employed in diagnostic research to identify biomarker profiles in mitochondrial disorders or immune deficiencies.
Overall, AK2 antibodies serve as essential reagents in both basic research and clinical studies, bridging molecular insights into energy metabolism, immune regulation, and disease pathogenesis. Their applications continue to expand as the role of AK2 in cellular stress responses and disease becomes clearer.
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