| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | IHC:1/100-1/200;IHF:1/50-1/200 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MT-TRX; MTRX; Thioredoxin2; TRX2; TXN2;;Thioredoxin 2 |
| WB Predicted band size | Calculated MW: 18 kDa ; Observed MW: 12 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Thioredoxin 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Thioredoxin 2(Trx2)抗体的3篇参考文献示例(虚构内容，供参考)：
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1. **文献名称**: *Mitochondrial Thioredoxin 2 modulates oxidative stress and apoptosis in mammalian cells*
**作者**: Smith J, et al.
**摘要**: 本研究利用特异性抗Trx2抗体，通过Western blot和免疫荧光技术验证了Trx2在线粒体中的定位，并发现其敲低导致细胞内ROS水平升高和细胞凋亡增加，表明Trx2在抗氧化防御中的关键作用。
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2. **文献名称**: *Development of a monoclonal antibody against human Trx2 for clinical biomarker analysis*
**作者**: Lee H, et al.
**摘要**: 作者开发了一种高亲和力的小鼠抗人Trx2单克隆抗体，验证了其在ELISA和免疫组化中的特异性，并用于检测心血管疾病患者血清中Trx2水平的变化，提示其作为氧化应激相关疾病的潜在生物标志物。
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3. **文献名称**: *Trx2 regulates mitochondrial function in neurodegenerative disease models*
**作者**: Chen R, et al.
**摘要**: 通过Trx2抗体介导的蛋白表达分析，揭示了Trx2在阿尔茨海默病模型小鼠脑组织中的表达下降，并证明其过表达可改善线粒体功能障碍，为神经退行性疾病的治疗提供新靶点。
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注：以上为示例文本，实际文献需通过PubMed、Google Scholar等平台以关键词“Thioredoxin2 antibody”或“Trx2 antibody”检索。
Thioredoxin 2 (Trx2) is a mitochondrial-specific antioxidant enzyme belonging to the thioredoxin family, which plays a critical role in maintaining cellular redox homeostasis. It contains a conserved dithiol active site (Cys-Gly-Pro-Cys) that enables it to reduce oxidized substrates, thereby neutralizing reactive oxygen species (ROS) and protecting mitochondrial components from oxidative damage. Trx2 is essential for regulating apoptosis by interacting with apoptosis signal-regulating kinase 1 (ASK1) and inhibiting its pro-apoptotic activity. It also supports mitochondrial DNA synthesis and repair, energy metabolism, and cell survival under stress conditions. Dysregulation of Trx2 has been implicated in various pathologies, including neurodegenerative diseases, cardiovascular disorders, cancer, and diabetes.
Antibodies targeting Trx2 are vital tools for studying its expression, localization, and function in both physiological and disease contexts. These antibodies enable detection of Trx2 via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the exploration of mitochondrial oxidative stress mechanisms. Specific Trx2 antibodies are often validated for cross-reactivity across species (e.g., human, mouse, rat) and tested for sensitivity to ensure accurate quantification. Research utilizing Trx2 antibodies has provided insights into its role in aging, metabolic syndromes, and therapeutic responses to redox-targeting drugs. Their application continues to advance understanding of mitochondrial biology and oxidative stress-related pathways.
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