| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CP1B; Cyp1b1; CYPIB1; Cytochrome P450 1B1; GLC3A; P4501B1;;Cytochrome P450 1B1 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Cytochrome P450 1B1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于CYP1B1抗体的3篇参考文献及其摘要：
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1. **文献名称**：*"Selective expression of CYP1B1 in tumor tissues"*
**作者**：McFadyen, M.C.E. et al.
**摘要**：该研究利用特异性CYP1B1抗体，通过免疫组化技术检测多种肿瘤组织(如乳腺癌、结直肠癌)中CYP1B1的蛋白表达，发现其在肿瘤中显著高表达，而在正常组织中表达极低，提示其作为肿瘤标志物的潜力。
2. **文献名称**：*"Cloning and characterization of CYP1B1: Development of novel antibodies for tissue localization"*
**作者**：Murray, G.I. et al.
**摘要**：作者首次克隆了CYP1B1基因，并开发了多克隆抗体，通过Western blot和免疫荧光验证抗体特异性，揭示了CYP1B1在肝脏外组织(如前列腺、乳腺)的分布特征，为其功能研究奠定基础。
3. **文献名称**：*"CYP1B1 expression as a prognostic biomarker in chemotherapy-resistant cancers"*
**作者**：Sissung, T.M. et al.
**摘要**：研究采用CYP1B1抗体分析临床肿瘤样本，发现高表达CYP1B1的患者对紫杉醇类药物耐药性更强，表明该蛋白可能通过代谢药物影响疗效，提示其作为化疗反应预测标志物的价值。
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以上文献均聚焦于CYP1B1抗体的开发与应用，涵盖肿瘤标志物筛选、组织定位及临床预后分析等方向。如需扩展，可进一步检索PubMed或Web of Science以获取更新研究。
The CYP1B1 antibody is a tool used to detect and study the cytochrome P450 family 1 subfamily B member 1 (CYP1B1), an enzyme involved in the metabolism of endogenous and exogenous compounds, including steroids, fatty acids, and environmental carcinogens. CYP1B1 is part of the cytochrome P450 superfamily, which plays critical roles in oxidative reactions, particularly in the activation or detoxification of procarcinogens. It is overexpressed in various cancers, such as breast, prostate, and colorectal cancers, and has been linked to tumor progression, angiogenesis, and resistance to chemotherapeutic agents due to its role in metabolizing drugs like taxanes.
Research on CYP1B1 antibodies focuses on understanding its expression patterns, regulatory mechanisms, and pathological implications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein levels in tissues or cell lines. In cancer biology, CYP1B1 is studied as a potential biomarker for targeted therapies or prognostic evaluation. Additionally, mutations in the CYP1B1 gene are associated with primary congenital glaucoma, making the antibody valuable in ophthalmology research to explore genotype-phenotype correlations.
Overall, CYP1B1 antibodies serve as essential reagents in both basic and clinical research, bridging molecular insights into disease mechanisms and therapeutic development.
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