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Rabbit Monoclonal NPRC Antibody

  • 中文名： NPRC抗体
  • 别    名： ANPC; ANPRC; GUCY2B; NPR 3; NPR C; Npr3; NPRC;;NPR3
货号: IPDX18098
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/20-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesANPC; ANPRC; GUCY2B; NPR 3; NPR C; Npr3; NPRC;;NPR3
WB Predicted band sizeCalculated MW: 60 kDa ; Observed MW: 70 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human NPR3
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于NPRC(利钠肽受体C)抗体的3篇代表性文献示例(注：内容为示例，非真实文献)：

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1. **文献名称**：*Characterization of NPRC-Specific Antibodies for Detecting Altered Receptor Expression in Heart Failure Models*

**作者**：Smith J. et al. (2021)

**摘要**：本研究开发并验证了一种高特异性NPRC多克隆抗体，用于检测心力衰竭小鼠心肌组织中NPRC蛋白的表达变化。通过Western blot和免疫组化证实，抗体可灵敏识别NPRC在心肌细胞膜上的定位，并发现心力衰竭模型中NPRC表达显著上调。

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2. **文献名称**：*NPRC Antibody Blockade Attenuates Tumor Growth via Modulation of cGMP Signaling*

**作者**：Zhang Y. et al. (2019)

**摘要**：利用NPRC中和抗体(克隆号：NPRC-3A7)阻断癌细胞表面受体活性，发现其可通过抑制cGMP/PKG通路抑制肿瘤增殖。研究在体外和异种移植模型中验证了抗体的有效性，为NPRC靶向治疗提供实验依据。

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3. **文献名称**：*Comparative Analysis of NPRC Isoform Expression in Human Adipose Tissue Using Novel Monoclonal Antibodies*

**作者**：Lee S. et al. (2020)

**摘要**：报道两种针对NPRC不同亚型(NPRC1和NPRC2)的单克隆抗体的开发，通过流式细胞术和免疫荧光验证其特异性。研究揭示肥胖患者脂肪组织中NPRC2亚型表达异常升高，提示其与代谢紊乱的潜在关联。

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**提示**：实际文献检索建议通过PubMed或Google Scholar使用关键词“NPRC antibody”、“NPRC receptor detection”等查询近年研究。

背景信息

The NPRC (Natrium Potassium Chloride Cotransporter) antibody is a crucial tool in studying ion transport mechanisms, particularly targeting the NKCC1 and NKCC2 proteins encoded by the SLC12A family. These transporters regulate cellular electrolyte balance by facilitating Na⁺-K⁺-2Cl⁻ symport across membranes. NKCC1 is widely expressed in secretory epithelia, neurons, and smooth muscle, playing roles in fluid secretion, cell volume regulation, and neuroexcitability. NKCC2. found predominantly in the kidney’s thick ascending limb, is essential for renal salt reabsorption and blood pressure regulation. NPRC antibodies enable detection, localization, and functional analysis of these transporters via techniques like Western blot, immunohistochemistry, and immunofluorescence. Research applications include investigating pathologies such as hypertension, epilepsy, and cystic fibrosis, where dysregulated ion transport is implicated. Additionally, these antibodies aid in exploring the pharmacodynamics of loop diuretics (e.g., furosemide), which target NKCC2. Developed in hosts like rabbits or mice, NPRC antibodies are validated for specificity through knockdown/knockout controls. Their utility spans physiology, pharmacology, and clinical research, offering insights into electrolyte homeostasis and therapeutic targeting.

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