| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NRP; NAP1; NAP1L;;NAP1L1 |
| WB Predicted band size | Calculated MW: 45 kDa ; Observed MW: 52,60 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human NAP1L1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于NAP1L1抗体的虚构参考文献示例(仅供示例用途，非真实文献)：
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1. **文献名称**: *NAP1L1 promotes hepatocellular carcinoma progression by modulating chromatin remodeling*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过免疫组化(使用兔源NAP1L1多克隆抗体)和Western blot分析，发现NAP1L1在肝细胞癌组织中高表达，并与患者预后不良相关。抗体特异性通过siRNA敲低实验验证，证实其可用于检测肿瘤中NAP1L1的亚细胞定位及表达水平。
2. **文献名称**: *Autoantibodies against NAP1L1 in neurodevelopmental disorders*
**作者**: Smith J, et al.
**摘要**: 研究利用ELISA和免疫印迹(抗NAP1L1单克隆抗体)筛查自闭症患者血清，发现NAP1L1自身抗体水平显著升高。抗体特异性经重组蛋白阻断实验确认，提示NAP1L1可能参与神经发育异常的免疫病理机制。
3. **文献名称**: *Role of NAP1L1 in embryonic stem cell pluripotency*
**作者**: Tanaka R, et al.
**摘要**: 通过免疫共沉淀(使用小鼠抗NAP1L1抗体)和ChIP-seq技术，揭示了NAP1L1与Oct4/Sox2复合物相互作用，调控多能性基因表达。抗体在干细胞分化模型中的应用证实了其在染色质结合研究中的可靠性。
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注：以上内容为示例，实际文献需通过PubMed、Google Scholar等平台检索。如需真实文献，建议使用关键词“NAP1L1 antibody”或“NAP1L1 immunohistochemistry”进行查询。
NAP1L1 (Nucleosome Assembly Protein 1-Like 1) is a conserved eukaryotic protein belonging to the NAP1 family, which plays critical roles in chromatin remodeling, histone chaperone activity, and nucleosome assembly. It facilitates the transport of histones H2A and H2B to sites of DNA replication and repair, ensuring proper nucleosome organization. NAP1L1 is implicated in regulating cell cycle progression, gene expression, and epigenetic modifications. Dysregulation of NAP1L1 has been linked to various cancers, neurodevelopmental disorders, and stem cell differentiation abnormalities, highlighting its biological and clinical relevance.
Antibodies targeting NAP1L1 are essential tools for studying its expression, localization, and interactions. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate NAP1L1's role in cellular processes. Specificity and validation are crucial, as NAP1L1 shares homology with other NAP family members. Commercial NAP1L1 antibodies are typically raised in hosts such as rabbits or mice, with both monoclonal and polyoclonal options available.
Research applications span cancer biology (tumor proliferation, metastasis), neurodevelopment (neuronal differentiation), and epigenetics (histone dynamics). Proper controls, including knockout cell lines or tissues, are recommended to confirm antibody specificity. NAP1L1 antibodies thus serve as vital reagents for unraveling its multifaceted contributions to health and disease.
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