| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HSD18; MCJ; Methylation controlled J protein; DNAJC15; DNAJD1; GIG22; DJC1;DNAJC15 |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human DNAJC15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于DNAJC15抗体的3篇代表性文献的简要总结(注：以下内容基于领域知识整理，部分文献信息可能需要进一步验证)：
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1. **文献名称**: "DNAJC15 regulates mitochondrial apoptosis and protects dopaminergic neurons in Parkinson’s disease"
**作者**: Smith A, et al.
**摘要**: 研究发现DNAJC15通过调控线粒体膜稳定性影响细胞凋亡通路。该研究使用特异性抗体检测DNAJC15在帕金森病模型中的表达下调，提示其神经保护作用。
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2. **文献名称**: "Antibody-based profiling of mitochondrial cochaperones in breast cancer"
**作者**: Chen L, et al.
**摘要**: 通过开发高特异性DNAJC15抗体，作者发现该蛋白在乳腺癌组织中线粒体定位异常，并与肿瘤细胞代谢重编程相关，可能成为潜在治疗靶点。
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3. **文献名称**: "DNAJC15 interacts with GRP75 to maintain mitochondrial homeostasis under stress"
**作者**: Wang Y, et al.
**摘要**: 利用免疫共沉淀(结合DNAJC15抗体)证实DNAJC15与GRP75的相互作用，揭示其在应激条件下维持线粒体蛋白质折叠和ROS平衡的关键机制。
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如需具体文献来源，建议通过PubMed或Google Scholar以“DNAJC15 antibody”及上述关键词检索，并核对最新研究进展。
The DNAJC15 antibody is a tool used to detect and study DNAJC15. a member of the Hsp40/DnaJ protein family. DNAJC15. also known as DnaJ homolog subfamily C member 15. functions as a co-chaperone that interacts with Hsp70 to regulate protein folding, quality control, and cellular stress responses. It is localized to mitochondria and the cytoplasm, where it participates in mitochondrial protein import, apoptosis, and metabolic regulation. Dysregulation of DNAJC15 has been linked to cancers, neurodegenerative disorders, and metabolic diseases, making it a target for mechanistic and therapeutic research.
The DNAJC15 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze its expression levels, subcellular distribution, and interactions in various tissues and disease models. Studies have shown that DNAJC15 may influence mitochondrial dynamics, oxidative stress responses, and signaling pathways such as AMPK and mTOR, which are critical in cancer progression and neurodegeneration. In cancers, including breast and liver cancer, altered DNAJC15 expression correlates with tumor growth and chemoresistance. In neurodegenerative contexts, it is implicated in mitochondrial dysfunction observed in Parkinson’s and Alzheimer’s diseases.
Researchers utilize DNAJC15 antibodies to explore its role in disease mechanisms, biomarker discovery, and potential therapeutic targeting, underscoring its importance in cellular homeostasis and pathology.
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