| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Int 1 related protein; INT1L 1; INT1L1; IRP; IRP protein; ONCOGENE INT1 LIKE 1; Protein Wnt-2; Secreted growth factor; Wingless type MMTV integration site family member 2; WNT2;;Wnt2 |
| WB Predicted band size | Calculated MW: 40 kDa ; Observed MW: 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Wnt2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于WNT2抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：
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1. **文献名称**: *WNT2 overexpression promotes tumor progression in gastric cancer through activation of the β-catenin signaling pathway*
**作者**: Li Y, et al.
**摘要**: 本研究利用抗WNT2抗体进行免疫组化分析，发现WNT2在胃癌组织中高表达，并与患者预后不良相关。通过体外实验证实，WNT2抗体可阻断WNT/β-catenin信号通路，抑制胃癌细胞侵袭。
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2. **文献名称**: *Dysregulated WNT2 signaling in colorectal cancer: Diagnostic and therapeutic implications*
**作者**: Smith JL, et al.
**摘要**: 通过Western blot和免疫荧光技术，研究者使用特异性WNT2抗体检测结直肠癌中WNT2蛋白的表达水平，发现其与肿瘤转移相关。抗体介导的WNT2功能抑制显著降低了小鼠模型中肿瘤的生长速度。
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3. **文献名称**: *Role of WNT2 in lung development and disease: Insights from antibody-based perturbation studies*
**作者**: Chen R, et al.
**摘要**: 本研究通过抗WNT2抗体阻断胚胎肺组织中的WNT2蛋白功能，揭示了WNT2在肺泡发育中的关键作用。免疫沉淀实验进一步证实了WNT2与Frizzled受体在肺上皮细胞中的相互作用。
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*注：以上文献为示例，实际引用需通过PubMed或Google Scholar等数据库检索真实研究。如需具体文章，建议使用关键词“WNT2 antibody”、“WNT2 immunohistochemistry”或“WNT2 signaling”进行查询。*
The WNT2 antibody is a research tool designed to detect and analyze the WNT2 protein, a member of the Wnt family of secreted glycoproteins. WNT proteins play critical roles in embryonic development, tissue homeostasis, and cell signaling, primarily through the evolutionarily conserved Wnt/β-catenin pathway. WNT2 specifically has been implicated in regulating processes such as cell proliferation, differentiation, and organogenesis, particularly in the development of the lung, gastrointestinal tract, and placenta. Dysregulation of WNT2 expression is associated with various pathologies, including cancer (e.g., colorectal, breast, and gastric cancers), fibrosis, and metabolic disorders.
Antibodies targeting WNT2 enable researchers to study its expression patterns, localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These tools are essential for investigating WNT2's role in both normal physiology and disease mechanisms. Commercially available WNT2 antibodies are typically raised in hosts like rabbits or mice, with validation across multiple applications. Recent studies using WNT2 antibodies have highlighted its potential as a biomarker in certain cancers and its involvement in tissue repair processes. However, challenges remain in ensuring antibody specificity due to structural similarities among Wnt family members. Ongoing research continues to explore WNT2's therapeutic potential, particularly in modulating Wnt signaling pathways implicated in regenerative medicine and oncology.
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