| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/20-1/50 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MGC1490; Rab 11; Rab 11A; Rab-11; RAB11 A; RAB11; Rab11a; RAB11A member RAS oncogene family; Ras related protein Rab 11A; Ras related protein Rab11A; Ras-related protein Rab-11A; RB11A; YL 8; YL8;;Rab11A |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Rab11A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于RAB11A抗体的文献概览(虚构示例，实际文献需通过数据库检索)：
1. **"RAB11A mediates vesicular trafficking during cytokinesis"**
- 作者：Smith J, et al.
- 摘要：研究利用RAB11A抗体通过免疫荧光(IF)和Western blot(WB)验证其在细胞分裂过程中调控囊泡运输的功能，揭示其与细胞膜修复的关联。
2. **"RAB11A-dependent exocytosis promotes viral entry"**
- 作者：Chen L, et al.
- 摘要：通过RAB11A抗体阻断实验，证明该蛋白在病毒(如流感病毒)内吞和释放过程中协调内体运输，影响病毒生命周期。
3. **"RAB11A overexpression correlates with poor prognosis in breast cancer"**
- 作者：Wang Y, et al.
- 摘要：使用RAB11A抗体进行组织芯片分析，发现其在乳腺癌中高表达，并与肿瘤转移和耐药性相关，提示其作为潜在治疗靶点。
4. **"RAB11A interacts with Parkinson's disease-linked proteins"**
- 作者：Garcia R, et al.
- 摘要：通过共聚焦显微镜(结合RAB11A抗体)发现其与α-synuclein和LRRK2的共定位，揭示其在神经退行性疾病中的囊泡运输调控机制。
如需真实文献，建议在PubMed或Google Scholar中搜索关键词“RAB11A antibody + [应用领域]”，筛选实验方法明确使用该抗体的研究。
RAB11A antibody is a key tool for studying the RAB11A protein, a member of the Ras-related GTPase RAB family involved in regulating intracellular vesicular trafficking. RAB11A primarily localizes to recycling endosomes and the trans-Golgi network, playing critical roles in cargo sorting, membrane recycling, and cytokinesis. It facilitates the transport of proteins and lipids between endosomal compartments, the plasma membrane, and secretory pathways, influencing processes like cell polarization, receptor recycling, and exosome secretion. Dysregulation of RAB11A is linked to cancers, neurological disorders, and ciliopathies, underscoring its biological and clinical relevance.
RAB11A antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to detect protein expression, subcellular localization, and interactions. Monoclonal antibodies offer high specificity, while polyclonal versions may detect conserved epitopes across species. Validated antibodies often undergo knockout cell line testing to confirm target specificity. These reagents are essential for investigating RAB11A’s functional mechanisms in membrane dynamics, autophagy, and cell division. Commercial RAB11A antibodies are available from major suppliers (e.g., Cell Signaling Technology, Abcam), with selection depending on experimental needs like species reactivity or compatibility with multiplex assays. Proper controls, including isotype-matched IgG and siRNA-mediated knockdown, are recommended to ensure data reliability.
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