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Rabbit Monoclonal TCEB2 Antibody

  • 中文名： TCEB2抗体
  • 别    名： EloB; Elongin B; SIII; SIII p18; Tceb2;;Elongin B
货号: IPDX17117
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesEloB; Elongin B; SIII; SIII p18; Tceb2;;Elongin B
WB Predicted band sizeCalculated MW: 13 kDa ; Observed MW: 16 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Elongin B
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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参考文献

以下是关于TCEB2抗体的3篇代表性文献摘要(内容基于公开研究整合，非真实文献，仅供示例参考)：

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1. **"TCEB2 regulates HIF-1α stability through Elongin BC complex in renal cell carcinoma"**

*作者：Kibel, A.S. et al.*

摘要：研究揭示TCEB2(Elongin B)作为Elongin BC复合体的核心组分，通过调控HIF-1α的泛素化降解影响肾癌细胞缺氧应答。文中使用TCEB2抗体进行免疫共沉淀(Co-IP)验证其与Elongin C的相互作用。

2. **"Functional characterization of Elongin B in transcriptional elongation"**

*作者：Conaway, J.W. & Conaway, R.C.*

摘要：探讨Elongin B(TCEB2)在RNA聚合酶II转录延伸中的作用，通过敲除实验和TCEB2抗体染色(ChIP-seq)证明其靶向结合基因启动子区域，调控癌症相关基因表达。

3. **"TCEB2 deficiency disrupts placental development in murine models"**

*作者：Ohh, M. et al.*

摘要：利用TCEB2基因敲除小鼠模型，发现TCEB2缺失导致胚胎致死性胎盘发育缺陷。研究通过Western blot(TCEB2抗体验证蛋白缺失)及组织染色，表明其通过VHL非依赖通路调控血管生成。

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*注：以上文献为示例，实际研究中建议通过PubMed或Google Scholar以“TCEB2 antibody”或“Elongin B”为关键词检索最新论文。*

背景信息

The TCEB2 antibody targets the Transcription Elongation Factor B (TCEB) subunit 2. a protein also known as Elongin B. TCEB2 is a key component of the Elongin complex, which plays a critical role in transcriptional regulation and protein ubiquitination. It forms a heterotrimeric complex with Elongin A (TCEB1) and Elongin C (TCEB3) to enhance RNA polymerase II transcriptional elongation. Additionally, TCEB2 interacts with the von Hippel-Lindau (VHL) tumor suppressor protein as part of the E3 ubiquitin ligase complex, facilitating hypoxia-inducible factor (HIF) degradation under normoxic conditions. Dysregulation of TCEB2 has been implicated in cancers, particularly renal cell carcinomas, where mutations in VHL or related pathways disrupt HIF regulation. Antibodies against TCEB2 are widely used in research to study its expression, localization, and interactions in cellular processes, including hypoxia response, DNA repair, and tumorigenesis. They are essential tools in techniques like Western blotting, immunoprecipitation, and immunohistochemistry. Recent studies also explore TCEB2’s role in modulating cullin-RING ligase (CRL) complexes, highlighting its broader impact on proteostasis and cellular signaling. As a conserved protein across eukaryotes, TCEB2 antibodies contribute to both basic molecular research and clinical investigations targeting cancer mechanisms.

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