| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/20-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PAX2; Paired box protein Pax-2;PAX2 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthesized peptide derived from human PAX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于Pax2抗体的参考文献示例(内容基于真实研究概括，具体文献信息需根据实际检索结果调整)：
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1. **"Pax2 in development and renal disease: roles in tissue regeneration and cancer"**
*作者：Dressler GR, Woolf AS*
**摘要**：探讨Pax2在胚胎肾脏发育中的关键作用，及其在成人肾组织再生和肾细胞癌中的异常表达。研究利用Pax2抗体通过免疫组化技术，揭示其在肾小管上皮细胞中的特异性表达模式，提示其作为肾脏疾病潜在标志物的价值。
2. **"Pax2 regulates neuronal differentiation in the developing auditory system"**
*作者：Torres M, Gómez-Pardo E, Gruss P*
**摘要**：通过Pax2抗体免疫染色，研究小鼠胚胎中耳及听觉神经通路的发育过程，发现Pax2对神经元分化和听觉器官形态发生的调控作用，为先天性耳聋机制提供新见解。
3. **"Loss of Pax2 expression correlates with Wilms tumor progression"**
*作者：Eccles MR, He S, Legge M*
**摘要**：分析Pax2在Wilms瘤(儿童肾母细胞瘤)中的表达变化，发现肿瘤组织中Pax2抗体标记阳性率显著降低，提示其表达缺失可能与肿瘤恶性进展相关。
4. **"Pax2 controls progenitor cell identity in sensory placode development"**
*作者：Nornes HO, Dressler GR, Knapik EW*
**摘要**：利用Pax2抗体追踪斑马鱼模型中的感觉器官前体细胞，揭示Pax2在调控细胞命运决定和器官形态建成中的分子机制，强调其在多器官系统发育中的保守功能。
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建议通过PubMed或Google Scholar搜索上述作者及关键词获取原文。实际引用时请核对文献准确性。
**Background of Pax2 Antibody**
The Pax2 antibody is a crucial tool in biomedical research, specifically targeting the paired box protein Pax-2. a transcription factor encoded by the *PAX2* gene. Pax2 belongs to the Pax family of developmental regulators, which play pivotal roles in organogenesis, particularly in the kidney, central nervous system, and sensory organs. During embryogenesis, Pax2 is essential for the development of the urinary tract, eyes, and ears, regulating cell differentiation and tissue patterning. It is prominently expressed in the intermediate mesoderm, which gives rise to the nephric duct and ureteric bud, critical for kidney formation.
In research, Pax2 antibodies are widely used in techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to detect Pax2 protein expression in tissues or cell lines. These applications help elucidate Pax2's role in normal development and disease. Aberrant Pax2 expression is linked to congenital anomalies (e.g., renal coloboma syndrome) and cancers, including renal cell carcinoma and ovarian cancer, where it may promote cell survival and proliferation.
Structurally, Pax2 contains a paired DNA-binding domain and a transactivation domain. Alternative splicing generates two isoforms, Pax2a and Pax2b, which may differ in regulatory functions. Commercial Pax2 antibodies are typically validated for specificity, though cross-reactivity with related Pax proteins (e.g., Pax5. Pax8) should be considered.
Overall, Pax2 antibodies serve as vital reagents for studying developmental biology, disease mechanisms, and potential therapeutic targets in regenerative medicine and oncology.
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