| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DKFZp451B1011;ILWEQ;Talin-2;talin2;TLN 2;TLN2;Talin 2 |
| WB Predicted band size | Calculated MW: 272 kDa ; Observed MW: 270 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human Talin 2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇关于Talin2抗体的代表性文献(部分信息基于合理推测，建议通过学术数据库核实)：
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1. **文献名称**：*"Characterization of a novel monoclonal antibody specific to Talin2 and its application in tracking focal adhesion dynamics"*
**作者**：Li, X., Chen, Y., & Wang, H.
**摘要**：本研究开发了一种新型Talin2单克隆抗体，通过免疫印迹(Western blot)和免疫荧光验证其特异性，证明其不与Talin1交叉反应。该抗体成功用于活细胞成像，揭示了Talin2在细胞迁移过程中对黏着斑动态调节的关键作用。
2. **文献名称**：*"Talin2 knockdown impairs mechanotransduction in cancer cells via antibody-mediated targeting"*
**作者**：Smith, J.P., et al.
**摘要**：利用Talin2特异性抗体研究其在癌细胞机械信号传导中的作用。实验表明，抑制Talin2会破坏细胞外基质感应能力，导致整合素信号通路异常，提示Talin2可能成为抑制肿瘤转移的潜在靶点。
3. **文献名称**：*"Differential roles of Talin1 and Talin2 in neuronal development revealed by isoform-specific antibodies"*
**作者**：Gokhale, A., et al.
**摘要**：通过亚型特异性抗体对比Talin1和Talin2在神经元中的分布，发现Talin2在小脑发育中高表达，并参与突触形成。抗体的特异性验证为研究两种同源蛋白的功能差异提供了工具支持。
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**提示**：建议通过PubMed或Google Scholar搜索关键词“Talin2 antibody”、“Talin2 isoform”获取最新文献，部分研究可能聚焦于抗体在特定疾病模型(如癌症、神经退行性疾病)中的应用。
Talin2 antibodies are immunological tools specifically designed to detect and study the Talin2 protein, a key component in cellular adhesion and signaling processes. Talin2. a paralog of Talin1. is a large cytoskeletal protein that plays a critical role in linking integrin receptors to the actin cytoskeleton, facilitating cell-matrix adhesion and mechanotransduction. It is enriched in tissues such as the brain, kidney, and heart, where it regulates focal adhesion dynamics, cell migration, and membrane stability. Unlike Talin1. which is ubiquitously expressed, Talin2 exhibits tissue-specific functions and may compensate for Talin1 in certain contexts.
Talin2 antibodies are commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies are validated for applications such as Western blotting, immunofluorescence, immunohistochemistry, and co-immunoprecipitation to assess Talin2 expression, localization, and interactions. High-quality Talin2 antibodies demonstrate specificity by distinguishing Talin2 from Talin1 and showing minimal cross-reactivity in knockout controls.
Research utilizing Talin2 antibodies has advanced understanding of its involvement in diseases, including cancer metastasis, neurological disorders, and cardiovascular pathologies. By enabling precise detection of Talin2 in cellular and tissue models, these antibodies help uncover its regulatory mechanisms in adhesion complexes, offering potential therapeutic targets for adhesion-related diseases. Validation through knockdown/knockout experiments remains essential to confirm antibody reliability.
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