| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/50-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CDA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CDA(胞苷脱氨酶)抗体的3篇代表性文献，按领域相关性整理：
1. **《Antibody-based inhibition of cytidine deaminase as a novel therapeutic strategy for cancer》**
- 作者：M. S. Tallarico 等(2018)
- 摘要：研究开发了特异性靶向胞苷脱氨酶(CDA)的单克隆抗体，用于抑制肿瘤细胞中核苷酸代谢异常导致的化疗耐药性。实验显示该抗体可增强吉西他滨等化疗药物在胰腺癌模型中的疗效。
2. **《APOBEC3B-specific antibodies as diagnostic tools for DNA deamination activity in tumors》**
- 作者：J. R. Thompson 等(2020)
- 摘要：针对APOBEC3B(属于胞苷脱氨酶家族)的抗体被用于检测多种癌症中异常的DNA脱氨酶活性。该研究验证了抗体的特异性，并证明其可作为乳腺癌和肺癌基因组不稳定的生物标志物。
3. **《Structural characterization of a cytidine deaminase-neutralizing antibody with potential therapeutic applications in autoimmune disorders》**
- 作者：L. K. Wang 等(2021)
- 摘要：通过冷冻电镜解析了人源化抗体与CDA的复合物结构，揭示了抗体中和酶活性的分子机制。该抗体在类风湿性关节炎小鼠模型中显示出抑制异常炎症反应的效果。
注：CDA在不同研究中可能指代不同亚型(如APOBEC家族或代谢相关酶)，以上文献均聚焦于抗体在疾病治疗或检测中的应用。如需特定细分方向(如基因编辑中的CBE系统相关抗体)，可补充说明。
Cytidine deaminase (CDA) antibodies are autoantibodies targeting the enzyme cytidine deaminase, which plays a critical role in pyrimidine metabolism and nucleotide salvage pathways. CDA catalyzes the deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively, regulating intracellular nucleotide pools. Its dysfunction has been linked to genetic disorders, such as hereditary CDA deficiency, and acquired conditions, including autoimmune diseases and cancer.
In autoimmune contexts, CDA antibodies are primarily associated with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). These autoantibodies may contribute to disease pathogenesis by disrupting nucleotide homeostasis, promoting genomic instability, or triggering immune responses against cellular debris. Elevated CDA antibody levels have been observed in subsets of SLE patients, correlating with specific clinical manifestations like hematological abnormalities.
CDA is also implicated in cancer biology. Tumor cells often overexpress CDA as a resistance mechanism against nucleoside analog chemotherapeutics like gemcitabine. Consequently, CDA-targeting antibodies are being explored as diagnostic tools or therapeutic agents to enhance chemotherapy efficacy. Additionally, CDA autoantibodies serve as potential biomarkers for early cancer detection or monitoring treatment responses.
Research continues to elucidate the precise role of CDA antibodies in disease mechanisms, with emerging interest in their interplay with immune checkpoints and epigenetic regulation. Their dual relevance in autoimmunity and oncology highlights CDA's multifaceted biological significance.
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