| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human FKBP5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
+ +
以下是关于FKBP5抗体的3篇示例文献(内容为模拟概括，建议通过学术数据库查询真实文献)：
---
1. **文献名称**：*FKBP5 Antibody Validation for Stress-Related Biomarker Studies*
**作者**：Smith A, et al.
**摘要**：该研究系统验证了多种FKBP5抗体的特异性，通过Western blot和免疫组化在小鼠脑组织中检测FKBP5表达，确认某商业抗体(如ABC公司#123)在敲除模型中无交叉反应，适用于神经科学领域研究。
---
2. **文献名称**：*Role of FKBP5 in Glucocorticoid Receptor Signaling Revealed by CRISPR-Cas9 Knockout Models*
**作者**：Chen L, et al.
**摘要**：利用CRISPR技术构建FKBP5敲除细胞系，结合特异性抗体(如Santa Cruz sc-12345)进行免疫沉淀和荧光显微镜观察，证明FKBP5缺失影响糖皮质激素受体核转位，抗体特异性经质谱验证。
---
3. **文献名称**：*FKBP5 Expression in Postmortem Human Brain Tissue: Implications for Psychiatric Disorders*
**作者**：Johnson R, et al.
**摘要**：通过免疫组化(使用抗体Abcam ab7890)分析抑郁症患者前额叶皮层FKBP5蛋白水平，发现其表达与表观遗传修饰相关，抗体特异性经肽段阻断实验证实，支持其在精神疾病病理研究中的应用。
---
**建议**：实际文献可通过PubMed、Google Scholar搜索关键词“FKBP5 antibody validation”或“FKBP5 immunohistochemistry”获取，优先选择近5年发表且经过同行评审的研究。
The FKBP5 antibody is a crucial tool for studying the FK506-binding protein 5 (FKBP5), a member of the immunophilin protein family involved in regulating glucocorticoid receptor (GR) sensitivity. FKBP5 acts as a cochaperone for heat shock protein 90 (HSP90), modulating GR ligand affinity and stress response pathways. Elevated FKBP5 expression reduces GR signaling by sequestering HSP90. impairing hormone binding and promoting cellular stress resilience. This protein is implicated in neuroendocrine disorders, anxiety, depression, and post-traumatic stress disorder (PTSD), as dysregulated FKBP5 expression alters hypothalamic-pituitary-adrenal (HPA) axis activity. Genetic variants in FKBP5 are linked to increased susceptibility to stress-related psychiatric conditions.
FKBP5 antibodies enable detection and quantification of FKBP5 in tissues and cells via techniques like Western blot, immunohistochemistry (IHC), and immunofluorescence (IF). They are vital for investigating FKBP5’s role in stress adaptation, GR trafficking, and interactions with molecular chaperones. Researchers also use these antibodies to explore FKBP5’s involvement in cancer, neurodegenerative diseases, and metabolic syndromes, where dysregulated FKBP5 may influence disease progression. Some antibodies target specific domains or post-translational modifications (e.g., phosphorylation sites) to dissect functional mechanisms. Species-specific variants (human, mouse, rat) are available for cross-species studies. As FKBP5 emerges as a biomarker and therapeutic target, its antibodies remain essential for both basic research and clinical applications.
×
