首页 / 产品 / 抗体 / 一抗

Mouse Monoclonal TXNDC5 Antibody

  • 中文名： TXNDC5抗体
  • 别    名： nan
货号: IPDX15158
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TXNDC5
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

参考文献

以下是关于TXNDC5抗体的3篇参考文献及其摘要概括：

1. **文献名称**：*TXNDC5 promotes hepatocellular carcinoma progression through induction of epithelial-mesenchymal transition*

**作者**：Wang Y, et al.

**摘要**：该研究通过TXNDC5抗体检测肝癌组织中TXNDC5的表达，发现其高表达与上皮-间质转化(EMT)和肿瘤转移相关，提示其作为肝癌预后标志物的潜力。

2. **文献名称**：*Thioredoxin domain-containing protein 5 (TXNDC5) exacerbates cardiac fibrosis via the HIF-1α/Smad3 pathway*

**作者**：Li X, et al.

**摘要**：利用TXNDC5抗体分析小鼠心脏组织，发现TXNDC5通过激活HIF-1α/Smad3通路促进心肌纤维化，为治疗心脏纤维化提供新靶点。

3. **文献名称**：*TXNDC5 drives extracellular matrix remodeling via endoplasmic reticulum stress in colorectal cancer*

**作者**：Chen J, et al.

**摘要**：通过TXNDC5抗体检测结直肠癌组织，发现其通过内质网应激调控细胞外基质重塑，增强肿瘤侵袭性，并影响患者生存率。

(注：以上文献为示例，实际引用需根据具体数据库检索结果调整。)

背景信息

The TXNDC5 (Thioredoxin domain-containing 5) antibody is a research tool used to study the expression and function of the TXNDC5 protein, a member of the thioredoxin family. TXNDC5. also known as endoplasmic reticulum protein 46 (ERp46), is a disulfide isomerase primarily localized in the endoplasmic reticulum (ER). It plays a critical role in oxidative protein folding, redox homeostasis, and ER stress response by catalyzing disulfide bond formation and rearrangement in nascent polypeptides. Dysregulation of TXNDC5 has been linked to various diseases, including cancer, cardiovascular disorders, and autoimmune conditions. For instance, elevated TXNDC5 levels are associated with tumor progression, angiogenesis, and metastasis in cancers like colorectal carcinoma and breast cancer. In cardiovascular contexts, it contributes to endothelial dysfunction and atherosclerosis. The TXNDC5 antibody enables detection and quantification of this protein in tissues or cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use it to explore TXNDC5's mechanistic roles in ER stress pathways, apoptosis, and inflammatory signaling. Commercial TXNDC5 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockdown models or recombinant protein assays. Its application advances understanding of diseases linked to redox imbalance and protein misfolding.

客户数据及评论

折叠内容

大包装询价

×