| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Gx; EN-7; HSPC022; p21-Rac2 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human RAC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TCL1B抗体的3篇参考文献及其摘要概括：
1. **"TCL1B acts as a tumor suppressor by inducing cell cycle arrest in colon cancer cells"**
- **作者**: Suzuki K, et al.
- **摘要**: 研究揭示了TCL1B在结肠癌中的抑癌作用，通过调控细胞周期蛋白(如p21和Cyclin D1)诱导G1期阻滞，并抑制AKT信号通路活性，提示其抗体可用于相关癌症的分子机制研究。
2. **"The TCL1 family of oncoproteins: co-activators of transformation"**
- **作者**: Pekarsky Y, Croce CM.
- **摘要**: 综述了TCL1家族蛋白(包括TCL1B)通过与AKT等信号分子相互作用促进细胞增殖和抑制凋亡的机制，强调其抗体在白血病及实体瘤研究中的工具价值。
3. **"Aberrant expression of TCL1B in B-cell chronic lymphocytic leukemia"**
- **作者**: Narducci MG, et al.
- **摘要**: 发现TCL1B在慢性淋巴细胞白血病(CLL)中异常高表达，并与疾病进展相关，利用特异性抗体检测其表达水平可作为潜在诊断标志物。
*注：文献为模拟示例，实际引用需核对真实数据库(如PubMed)。若需具体文献，建议补充研究背景或应用场景。*
The TCL1B antibody is designed to target the T-cell leukemia 1B (TCL1B) protein, a member of the TCL1 family, which includes TCL1A, TCL1B, and MTCP1. These proteins are implicated in regulating cell survival and proliferation, primarily through interactions with AKT kinase, enhancing its activation and promoting oncogenic signaling pathways. TCL1B shares structural and functional similarities with TCL1A, both forming homodimers or heterodimers to stabilize AKT, thereby influencing cell growth and apoptosis.
The TCL1 family gained attention due to its association with T-cell leukemias and lymphomas. Chromosomal translocations involving the TCL1B locus (e.g., rearrangements with T-cell receptor genes) can lead to its aberrant overexpression, contributing to malignant transformation of T-cells. While TCL1A is more extensively studied, TCL1B is less characterized but believed to play overlapping or distinct roles in specific cellular contexts.
TCL1B antibodies are critical tools in research, enabling the detection of TCL1B protein expression in normal and cancerous tissues. They aid in studying its role in hematologic malignancies, immune regulation, and potential as a diagnostic or prognostic biomarker. Additionally, these antibodies support investigations into TCL1B's interaction networks and its therapeutic targeting in cancers with dysregulated AKT signaling. Ongoing research aims to clarify TCL1B's precise biological functions and its utility in clinical applications.
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