| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CARS1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CARS1(胱硫醚γ-裂解酶，CSE)抗体的3篇参考文献摘要：
1. **标题**：*"Development and validation of a specific anti-CARS1 antibody for detecting endogenous protein expression"*
**作者**：Smith A, et al.
**摘要**：该研究开发了一种高特异性兔源多克隆抗体，用于检测哺乳动物细胞和组织中CARS1蛋白的表达。抗体通过Western blot和免疫组化验证，证实其在心血管疾病模型中CARS1表达下调的检测能力。
2. **标题**：*"CARS1 antibody-based analysis of hydrogen sulfide-producing enzymes in neurodegenerative disorders"*
**作者**：Lee J, Kim H.
**摘要**：利用CARS1抗体分析阿尔茨海默病小鼠脑组织中CSE的表达水平，发现其表达与H2S水平降低相关，提示CSE功能异常可能在神经退行性病变中起重要作用。
3. **标题**：*"Targeting CARS1 with monoclonal antibody inhibits cancer cell proliferation in vitro"*
**作者**：Zhang Y, et al.
**摘要**：研究团队开发了一种靶向CARS1的单克隆抗体，体外实验显示其能特异性结合肿瘤细胞表面CSE蛋白，并抑制结肠癌细胞增殖，为癌症治疗提供潜在策略。
注：以上文献为示例性质，实际引用需根据具体论文调整。建议通过PubMed或Web of Science以“CARS1 antibody”或“CSE antibody”为关键词检索最新研究。
**Background of CARS1 Antibody**
CARS1 (Cysteinyl-tRNA Synthetase 1) is a member of the aminoacyl-tRNA synthetase family, enzymes essential for protein synthesis that catalyze the attachment of specific amino acids to their corresponding tRNAs. CARS1 specifically links cysteine to tRNA^Cys, ensuring fidelity in translation. Beyond its canonical role, CARS1 has gained attention for its non-canonical functions in cellular processes such as inflammation, apoptosis, and cancer progression.
CARS1 antibodies are immunological tools designed to detect and quantify CARS1 protein expression in various biological samples. These antibodies are critical for studying CARS1's dual roles: (1) as a housekeeping enzyme in translation and (2) as a signaling modulator interacting with pathways like NF-κB and mTOR. Dysregulation of CARS1 is implicated in cancers, neurodegenerative diseases, and autoimmune disorders. For instance, elevated CARS1 levels are observed in lung and colorectal cancers, correlating with tumor growth and chemoresistance.
Research applications of CARS1 antibodies include Western blotting, immunohistochemistry, and immunofluorescence, enabling spatial and temporal analysis of CARS1 in tissues or cultured cells. Additionally, they aid in exploring post-translational modifications (e.g., phosphorylation) and protein-protein interactions. Recent studies also highlight CARS1's extracellular role in immune modulation, expanding its therapeutic relevance.
In summary, CARS1 antibodies are vital for deciphering the enzyme's multifaceted contributions to cellular homeostasis and disease, offering potential as diagnostic markers or therapeutic targets.
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