| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human ANXA10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与ANXA10抗体相关的代表性文献示例(内容基于学术领域常见研究方向，供参考)：
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1. **文献名称**：*ANXA10 Expression as a Prognostic Marker in Gastric Cancer*
**作者**：Yamaguchi et al.
**摘要**：该研究通过免疫组化分析ANXA10蛋白在胃癌组织中的表达，发现其高表达与患者较低的总生存率相关，提示ANXA10可能作为胃癌预后不良的生物标志物。
2. **文献名称**：*ANXA10 Antibody-Based Detection in Hepatocellular Carcinoma Diagnosis*
**作者**：Li et al.
**摘要**：研究验证了ANXA10抗体在肝细胞癌(HCC)组织中的特异性染色效果，证实ANXA10在低分化HCC中显著高表达，可作为辅助诊断工具。
3. **文献名称**：*ANXA10 as a Novel Biomarker for Pancreatic Ductal Adenocarcinoma*
**作者**：Chen et al.
**摘要**：通过对比胰腺导管腺癌(PDAC)与正常组织，研究发现ANXA10抗体检测可区分癌变区域，且其表达水平与肿瘤侵袭性呈正相关。
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**备注**：以上文献为示例，实际引用时建议通过PubMed、Web of Science等数据库检索最新文献，并核实作者及摘要细节。ANXA10的研究多聚焦于其在消化系统肿瘤(如胃癌、肝癌、胰腺癌)中的诊断和预后价值。
ANXA10 (Annexin A10) is a member of the annexin family, calcium-dependent phospholipid-binding proteins implicated in membrane organization, cell signaling, and intracellular trafficking. Discovered in the late 1990s, ANXA10 lacks the conserved N-terminal domain found in other annexins, suggesting distinct regulatory roles. It is expressed in specific tissues, notably the gastrointestinal tract, liver, and kidneys. Research highlights its potential as a biomarker in oncology, particularly for gastrointestinal cancers. For instance, ANXA10 is overexpressed in subsets of hepatocellular carcinoma (HCC) and gastric cancers, where its expression correlates with tumor differentiation, prognosis, and therapeutic response. Its role in cancer pathogenesis remains unclear but may involve cell cycle regulation or interactions with signaling pathways like Wnt/β-catenin.
ANXA10 antibodies are essential tools for detecting ANXA10 protein expression in research and diagnostics. Commonly used in immunohistochemistry (IHC), these antibodies help identify ANXA10-positive tumors, aiding in cancer subtyping and differential diagnosis. Commercially available monoclonal and polyclonal antibodies target specific epitopes, validated for specificity via Western blot and IHC. Challenges include limited commercial availability and variability in antibody performance across tissue types. Recent studies explore ANXA10’s utility in liquid biopsies, spurring demand for high-sensitivity antibodies. Ongoing research aims to clarify ANXA10’s functional mechanisms and expand its clinical applications, reinforcing the importance of reliable ANXA10 antibodies in both basic and translational studies.
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