关键信息
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基因名
CD127/IL-7RA
- 应用
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别名
Interleukin-7 receptor subunit alpha; IL7R; IL-7R-alpha; CD127
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种属
Human
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表达系统
HEK293
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标签
C-mFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P16871-1
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表达区间
E21-G236, I66T, V138I
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蛋白长度
Extracellular Domain
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分子量
75-95 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD127, also known as interleukin-7 receptor alpha (IL-7RA), plays a crucial role in the immune system, particularly in lymphocyte differentiation and homeostasis. It is a vital component of the IL-7 receptor complex, which mediates the effects of interleukin-7 (IL-7), a cytokine essential for T cell development and survival. Dysfunction in this receptor has been associated with various immunodeficiencies, autoimmune diseases, and even cancer, highlighting its significance in maintaining immune balance. Research into CD127/IL-7RA recombinant proteins has gained momentum as scientists seek to understand its structural and functional characteristics. By producing recombinant forms of the IL-7RA protein, researchers aim to investigate its interaction with IL-7 and its role in T cell maturation. These studies can provide insights into therapeutic applications, especially in designing targeted treatments for conditions like HIV/AIDS, where T cell depletion occurs, or in enhancing T cell responses in cancer immunotherapy. The development of CD127/IL-7RA recombinant proteins also opens avenues for producing monoclonal antibodies that could modulate immune responses. Overall, the exploration of CD127/IL-7RA recombinant proteins represents a significant step forward in immunological research, holding promise for novel immunotherapeutic strategies and a deeper understanding of immune regulation.
