Rabbit Polyclonal COX19 Antibody

The COX19 antibody is a research tool used to detect the COX19 protein, a conserved component involved in mitochondrial cytochrome c oxidase (Complex IV) assembly. COX19. part of the cytochrome c oxidase assembly pathway, functions as a chaperone-like protein facilitating copper delivery and metallation of catalytic subunits within the mitochondrial intermembrane space. It shares structural features with thioredoxin-like proteins, suggesting roles in redox regulation or disulfide bond formation during Complex IV biogenesis. Studies in yeast homologs highlight its importance in maintaining respiratory competence, with defects linked to mitochondrial disorders. Mammalian COX19 is ubiquitously expressed but enriched in high-energy-demand tissues, such as heart and brain. Researchers employ COX19 antibodies in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study its expression, subcellular localization, and interactions under physiological or pathological conditions, including neurodegenerative diseases and cancers associated with mitochondrial dysfunction. These antibodies help elucidate COX19's regulatory mechanisms in cellular respiration and oxidative stress responses, offering insights into diseases linked to impaired energy metabolism.