| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/5000 | Human,Mouse,Rat |
| Aliases | CLG3, MANDP1 |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MMP13 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于MMP13抗体的参考文献概览(信息基于公开研究整理，具体内容请参考原文)：
1. **文献名称**: "MMP13 promotes tumor invasion through collagen remodeling in the stromal microenvironment"
**作者**: Li et al.
**摘要**: 研究利用MMP13抗体检测肿瘤微环境中MMP13的分布，发现其通过降解胶原促进癌细胞侵袭，抗体阻断可抑制转移。
2. **文献名称**: "Regulation of MMP13 expression in osteoarthritis: Role of inflammatory cytokines"
**作者**: Wang et al.
**摘要**: 通过免疫组化(MMP13抗体标记)分析骨关节炎患者软骨组织，证实IL-1β和TNF-α上调MMP13表达，加速软骨退化。
3. **文献名称**: "Targeting MMP13 with a monoclonal antibody attenuates skeletal muscle fibrosis"
**作者**: Smith et al.
**摘要**: 开发一种高特异性MMP13单克隆抗体，在动物模型中验证其抑制纤维化相关胶原沉积的能力，提示治疗组织修复异常的潜力。
4. **文献名称**: "MMP13-neutralizing antibody therapy reduces angiogenesis in diabetic retinopathy models"
**作者**: Chen & Kumar
**摘要**: 利用MMP13抗体阻断酶活性，发现其可减少病理性血管生成，为糖尿病视网膜病变提供潜在治疗策略。
如需具体文章细节或全文链接，建议通过PubMed或期刊数据库检索作者及标题。
Matrix metalloproteinase 13 (MMP13), a member of the MMP family, is a zinc-dependent endopeptidase involved in degrading extracellular matrix (ECM) components, particularly type II collagen. It plays critical roles in physiological processes like tissue remodeling, wound healing, and bone development, but its dysregulation is linked to pathological conditions such as osteoarthritis, cancer metastasis, and chronic inflammation. In osteoarthritis, MMP13 overexpression accelerates cartilage degradation by breaking down collagen networks, making it a key therapeutic target.
MMP13 antibodies are immunodetection tools designed to specifically recognize and bind to MMP13 proteins. These antibodies, often monoclonal or polyclonal, are widely used in research to study MMP13 expression patterns, localization, and activity in tissues or biofluids. Applications include immunohistochemistry, Western blotting, and ELISA. Some antibodies distinguish between latent (pro-MMP13) and active enzyme forms, aiding mechanistic studies. Additionally, therapeutic MMP13-neutralizing antibodies are under exploration to inhibit excessive collagenolysis in diseases like osteoarthritis, though challenges remain in balancing efficacy and off-target effects.
As a biomarker, MMP13 antibody-based assays help correlate enzyme levels with disease progression. Their development continues to advance understanding of MMP13's pathophysiological roles and potential intervention strategies.
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