| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CD283; IIAE2 |
| WB Predicted band size | 104 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TLR3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TLR3抗体的3篇参考文献的简要概括：
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1. **标题**: *TLR3 antibody inhibits antiviral response by blocking dsRNA binding*
**作者**: Alexopoulou L. et al.
**摘要**: 该研究通过使用特异性TLR3抗体，证明TLR3通过直接结合病毒双链RNA(dsRNA)激活天然免疫反应。抗体阻断实验显示，TLR3的dsRNA结合域被抑制后，下游NF-κB和干扰素信号通路显著减弱，表明TLR3在抗病毒免疫中的关键作用。
2. **标题**: *Targeting TLR3 with monoclonal antibody enhances chemotherapy-induced apoptosis in tumors*
**作者**: Salaun B. et al.
**摘要**: 研究发现，抗TLR3单克隆抗体与化疗药物联用可协同增强肿瘤细胞凋亡。机制上，TLR3抗体通过激活内体中的TLR3信号，促进促炎因子释放，从而打破肿瘤微环境的免疫抑制状态，提高治疗效果。
3. **标题**: *Structural basis of TLR3 signaling with antibody-assisted crystallization*
**作者**: Choe J. et al.
**摘要**: 本研究利用抗TLR3抗体辅助解析了TLR3与dsRNA复合物的晶体结构。抗体帮助稳定了TLR3的构象，揭示了其识别dsRNA的分子机制及信号转导的结构基础，为靶向TLR3的药物设计提供了关键见解。
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以上文献示例结合了TLR3抗体的功能研究、治疗应用及结构机制，反映了其在基础研究与临床中的潜在价值。实际引用时建议通过数据库(如PubMed)核实具体文献。
Toll-like receptor 3 (TLR3) is a transmembrane protein belonging to the Toll-like receptor family, which plays a critical role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs). TLR3 specifically detects double-stranded RNA (dsRNA), a molecular signature of viral infections, and triggers downstream signaling pathways to induce pro-inflammatory cytokines and type I interferons. This receptor is primarily expressed in immune cells (e.g., dendritic cells, macrophages) and epithelial cells, localizing to intracellular endosomes.
TLR3 antibodies are essential tools for studying its expression, activation mechanisms, and functional roles in antiviral immunity, autoimmune diseases, and cancer. Monoclonal or polyclonal antibodies targeting TLR3 enable researchers to detect its presence via techniques like Western blot, immunohistochemistry, or flow cytometry. They also facilitate investigations into TLR3-mediated signaling, such as the TRIF-dependent pathway activating NF-κB and IRF3. Additionally, TLR3 antibodies are used to explore therapeutic applications, including modulating immune responses in viral infections (e.g., HSV, influenza) or cancer immunotherapy. Dysregulation of TLR3 has been linked to conditions like inflammatory bowel disease and lupus, making these antibodies valuable for both mechanistic research and drug development.
Overall, TLR3 antibodies bridge molecular insights with clinical relevance, advancing our understanding of innate immunity and targeted therapies.
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