| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MMP-7, MPSL1, PUMP-1 |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MMP7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与MMP7抗体相关的模拟参考文献(基于常见研究方向，非真实文献)：
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1. **文献名称**: *MMP7 Antibody-Based Immunohistochemical Analysis in Colorectal Cancer Metastasis*
**作者**: Yamamoto H., et al.
**摘要**: 研究采用特异性MMP7抗体，通过免疫组化分析结直肠癌组织样本，发现MMP7高表达与淋巴结转移及患者预后不良显著相关，提示其作为转移性生物标志物的潜在价值。
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2. **文献名称**: *Development of a High-Affinity MMP7 Monoclonal Antibody for Therapeutic Targeting in Pancreatic Cancer*
**作者**: Smith J.R., et al.
**摘要**: 报道一种新型抗MMP7单克隆抗体的开发与验证，该抗体在胰腺癌模型中能特异性结合并抑制MMP7活性，显著降低肿瘤侵袭性，为靶向治疗提供实验依据。
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3. **文献名称**: *MMP7 Autoantibody as a Serological Biomarker for Early Detection of Hepatocellular Carcinoma*
**作者**: Li X., et al.
**摘要**: 通过ELISA检测患者血清中MMP7自身抗体水平，发现其在肝细胞癌早期诊断中具有较高敏感性和特异性，可能成为非侵入性筛查工具。
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注：以上文献为模拟示例，实际引用时需查询真实数据库(如PubMed)并核对原文信息。
Matrix metalloproteinase 7 (MMP7), also known as matrilysin, is a member of the zinc-dependent endopeptidase family involved in extracellular matrix (ECM) remodeling. It primarily degrades components like elastin, fibronectin, and proteoglycans, playing roles in tissue repair, inflammation, and cancer progression. MMP7 is secreted as an inactive zymogen and activated via proteolytic cleavage. Unlike other MMPs, it lacks a hemopexin domain, contributing to its compact structure and substrate specificity.
MMP7 antibodies are essential tools for detecting and quantifying MMP7 expression in research and diagnostics. They are widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to study MMP7's involvement in pathological processes. Elevated MMP7 levels are linked to tumor invasion, metastasis, and poor prognosis in cancers (e.g., colorectal, pancreatic, and breast cancers), as well as fibrotic and inflammatory diseases.
Clinically, MMP7 antibodies aid in developing therapeutic strategies, including inhibitory drugs or antibody-based therapies targeting MMP7 overexpression. However, challenges remain due to MMP7's dual role in both promoting disease and maintaining tissue homeostasis. Ongoing research focuses on understanding its regulatory mechanisms and context-dependent functions to refine therapeutic targeting.
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