关键信息
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基因名
MAP2K7
- 应用
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别名
Jnkk2; MAPKK7; MKK7; PRKMK7; SKK4; JNK-activating kinase 2; Stress-activated protein kinase kinase 4; c-Jun Nterminal kinase kinase 2
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种属
Human
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表达系统
E. coli
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标签
N-6His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14733
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表达区间
113-388aa
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分子量
35kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MAP2K7, also known as JNK kinase or MKK7, is a vital component of the mitogen-activated protein kinase (MAPK) signaling cascade, specifically involved in the activation of c-Jun N-terminal kinases (JNKs). This pathway plays a crucial role in cellular responses to various stress stimuli, including inflammation, apoptosis, and cell proliferation. Due to its significant involvement in these processes, MAP2K7 has garnered considerable interest in cancer research, neurodegenerative diseases, and other pathologies. Studies have shown that dysregulation of the MAPK pathway, including MAP2K7, is linked to tumor progression and metastasis, making it a potential target for therapeutic interventions. The recombinant expression of MAP2K7 allows for in-depth studies of its biochemical properties, substrate interactions, and regulatory mechanisms. Furthermore, producing MAP2K7 as a recombinant protein facilitates the exploration of its role in various signaling pathways under controlled experimental conditions. This, in turn, aids in understanding its functional implications in health and disease, leading to potential approaches for targeted therapies. Understanding the structure-function relationship of MAP2K7 through recombinant protein studies may open new avenues for drug design, particularly in targeting specific pathways influenced by JNK signaling in diseases such as cancer and chronic inflammatory conditions. Overall, the investigation of recombinant MAP2K7 holds the promise of elucidating its precise biological roles and therapeutic potential in various diseases.
