| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GK1; GKD |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GK |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF251 (N-term)抗体的参考文献示例(内容为虚构，仅供参考)：
1. **文献名称**：*ZNF251 N-terminal antibody validation in transcriptional regulation studies*
**作者**：Smith A, et al.
**摘要**：该研究利用ZNF251 (N-term)抗体进行Western blot和免疫沉淀实验，验证了ZNF251蛋白在多种癌细胞系中的表达，并探讨其通过N端结构域参与基因沉默的机制。
2. **文献名称**：*Role of ZNF251 in DNA damage response: Evidence from ChIP-seq analysis*
**作者**：Lee J, et al.
**摘要**：通过ZNF251 (N-term)抗体的染色质免疫沉淀(ChIP-seq)，作者发现ZNF251通过N端锌指结构域靶向结合DNA损伤修复相关基因的启动子区域。
3. **文献名称**：*Developmental expression profiling of ZNF251 using N-terminal specific antibodies*
**作者**：Garcia R, et al.
**摘要**：研究使用ZNF251 (N-term)抗体进行免疫组化分析，揭示了该蛋白在小鼠胚胎发育不同阶段的组织特异性表达模式，提示其在细胞分化中的作用。
4. **文献名称**：*ZNF251 interacts with HDAC1: A study co-localized by immunofluorescence*
**作者**：Chen L, et al.
**摘要**：通过ZNF251 (N-term)抗体的免疫荧光共定位实验，证实ZNF251的N端区域与组蛋白去乙酰化酶HDAC1存在相互作用，可能参与表观遗传调控。
注：以上文献为示例，实际引用需根据真实发表的论文调整。建议通过PubMed、Google Scholar或抗体供应商(如CST、Abcam)官网检索具体文献。
The ZNF251 (N-term) antibody targets the N-terminal region of zinc finger protein 251 (ZNF251), a member of the Krüppel-associated box (KRAB)-containing zinc finger protein (ZNF) family. These proteins are characterized by tandem C₂H₂ zinc finger motifs that mediate sequence-specific DNA binding, often regulating gene expression through epigenetic modifications. ZNF251 is implicated in transcriptional repression, potentially interacting with chromatin-remodeling complexes via its KRAB domain, which recruits corepressors. The N-terminal region may also play a role in protein-protein interactions or subcellular localization.
This antibody is commonly used in research to detect ZNF251 in techniques like Western blotting, immunofluorescence, or chromatin immunoprecipitation (ChIP), aiding in studies of its expression patterns, molecular functions, and involvement in cellular processes such as differentiation or tumor suppression. Specificity for the N-terminus helps distinguish ZNF251 from homologous proteins or splice variants. Validation typically includes knockout controls or peptide blocking assays to confirm reactivity. Dysregulation of ZNF proteins is linked to cancers and developmental disorders, making ZNF251 a potential biomarker or therapeutic target. The antibody's utility lies in unraveling ZNF251's role in gene regulatory networks and disease mechanisms.
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