Rabbit Polyclonal MousePrr5 Antibody

The Mouse Proline-rich protein 5 (Prr5) antibody is a tool used to detect and study the Prr5 protein, also known as PROTOR2 (PRR5L), in murine models. Prr5 is a conserved, evolutionarily conserved component of the mammalian target of rapamycin complex 2 (mTORC2), which regulates cell survival, proliferation, and metabolic processes. Structurally, Prr5 contains a proline-rich N-terminal domain and a C-terminal region critical for mTORC2 interaction. It plays a role in stabilizing mTORC2 assembly and modulating its activity toward downstream targets like Akt (Ser473 phosphorylation). Research using Mouse Prr5 antibodies has highlighted its involvement in cellular stress responses, apoptosis regulation, and tissue-specific functions, particularly in the liver, adipose tissue, and immune cells. Antibodies against murine Prr5 are commonly validated via Western blotting, immunoprecipitation, or immunofluorescence to assess protein expression, localization, and interaction dynamics. These tools are essential for investigating Prr5's role in diseases linked to mTORC2 dysregulation, such as cancer, metabolic disorders, and immune dysfunctions. Specificity and validation data (e.g., knockout controls) are critical to ensure reliable detection, given sequence similarities with human PRR5 or related isoforms.