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| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BMP10 |
| Uniprot No | O95393 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 317-424aa |
| 氨基酸序列 | NAKG NYCKRTPLYI DFKEIGWDSW IIAPPGYEAY ECRGVCNYPL AEHLTPTKHA IIQALVHLKN SQKASKACCV PTKLEPISIL YLDKGVVTYK FKYEGMAVSE CGCR |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于BMP10重组蛋白的3篇模拟参考文献示例(注：文献信息为假设性概括，仅供参考)：
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1. **文献名称**：*Recombinant Human BMP10 Promotes Cardiomyocyte Proliferation via ALK1 Signaling*
**作者**：Li, Y. et al.
**摘要**：本研究利用重组人BMP10蛋白，验证其通过激活ALK1/Smad1通路促进心肌细胞增殖的作用，为心脏再生治疗提供潜在靶点。
2. **文献名称**：*Expression and Purification of Functional BMP10 in a Mammalian Cell System*
**作者**：Wang, Q. et al.
**摘要**：开发了一种基于HEK293细胞的重组BMP10蛋白表达与纯化方法，证实其生物活性可通过体外心肌细胞实验验证。
3. **文献名称**：*BMP10 Inhibits Pathological Vascular Remodeling in Pulmonary Hypertension*
**作者**：Garcia, J.A. et al.
**摘要**：通过动物模型证明，重组BMP10蛋白可抑制肺动脉高压中的异常血管增生，机制涉及内皮细胞功能调控。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“recombinant BMP10 protein”或“BMP10 function”，筛选近年研究。例如：
- **实际文献参考**(需验证)：
- *BMP10 is essential for maintaining cardiomyocyte renewal in the adult heart* (D'Amato, G. et al., *Nature Communications*, 2016)
- *BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cells* (Tran, S. et al., *Stem Cell Reports*, 2021)
Bone morphogenetic protein 10 (BMP10), a member of the transforming growth factor-beta (TGF-β) superfamily, plays a critical role in cardiovascular development and tissue homeostasis. Primarily expressed in the developing heart, BMP10 is essential for regulating cardiomyocyte proliferation, chamber maturation, and ventricular wall formation during embryogenesis. In adults, its expression becomes restricted to the right atrium but retains functional significance in maintaining cardiac structure and modulating pressure overload responses.
Recombinant BMP10 protein is produced using biotechnological systems (e.g., mammalian cell cultures) to ensure proper post-translational modifications and biological activity. This engineered protein typically consists of the mature peptide region, which binds to type I (ALK1. ALK3) and type II (BMPRII) receptors, activating SMAD-dependent signaling pathways. Its structural integrity, including conserved cysteine residues critical for dimerization, is crucial for receptor interaction and downstream effects.
Research applications focus on BMP10's dual role as a growth regulator and potential therapeutic target. Studies utilize recombinant BMP10 to investigate congenital heart defects, myocardial remodeling, and pulmonary arterial hypertension. Notably, it shows paradoxical characteristics – while promoting embryonic heart growth, it may inhibit pathological cardiac hypertrophy in adults. Emerging evidence also explores its involvement in angiogenesis and cancer biology, particularly in tumors with cardiovascular comorbidities.
Clinically, BMP10 levels are being evaluated as biomarkers for heart failure progression. Therapeutic strategies aim to modulate its signaling pathway using recombinant proteins or neutralizing antibodies, offering potential interventions for cardiovascular diseases and tissue regeneration. However, challenges remain in understanding its context-dependent signaling mechanisms and optimizing delivery approaches for clinical translation.
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