| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | UBADC1 |
| Uniprot No | Q9BSL1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-405 aa |
| 活性数据 | MFVQEEKIFAGKVLRLHICASDGAEWLEEATEDTSVEKLKERCLKHCAHGSLEDPKSITHHKLIHAASERVLSDARTILEENIQDQDVLLLIKKRAPSPLPKMADVSAEEKKKQDQKAPDKEAILRATANLPSYNMDRAAVQTNMRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEDERVDEAALRQLTEMGFPENRATKALQLNHMSVPQAMEWLIEHAEDPTIDTPLPGQAPPEAEGATAAASEAAAGASATDEEARDELTEIFKKIRRKREFRADARAVISLMEMGFDEKEVIDALRVNNNQQNAACEWLLGDRKPSPEELDKGIDPDSPLFQAILDNPVVQLGLTNPKTLLAFEDMLENPLNSTQWMNDPETGPVMLQISRIFQTLNRT |
| 分子量 | 45.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人UBADC1蛋白的3篇参考文献示例(基于研究主题合理推测，实际文献可能需要通过数据库核实)：
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1. **文献名称**：**Structural and Functional Characterization of Recombinant Human UBADC1 Protein**
**作者**：Smith, J. et al.
**摘要**：该研究通过大肠杆菌系统成功表达并纯化了重组人UBADC1蛋白，解析了其晶体结构，揭示其泛素结合域的关键作用。实验表明UBADC1通过特定结构域与泛素酶复合物相互作用，可能参与调控蛋白质降解通路。
2. **文献名称**：**UBADC1 Modulates Cell Cycle Progression via Interaction with Ubiquitin Ligases**
**作者**：Chen, L. et al.
**摘要**：作者利用重组UBADC1蛋白进行体外结合实验，发现其与E3泛素连接酶(如MDM2)直接结合，并在细胞周期调控中起重要作用。敲低UBADC1导致细胞周期停滞，提示其在肿瘤发生中的潜在功能。
3. **文献名称**：**Recombinant UBADC1 as a Biomarker for Neurodegenerative Disease Progression**
**作者**：Wang, Y. et al.
**摘要**：研究开发了基于重组UBADC1蛋白的检测方法，发现其在阿尔茨海默病患者的脑脊液中表达异常。体内实验表明，UBADC1通过调节错误折叠蛋白的泛素化水平参与神经退行性病变。
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**备注**：以上文献为示例，实际引用时建议通过PubMed、Google Scholar等平台以“UBADC1”、“recombinant UBADC1”为关键词检索最新研究，并核实作者及摘要细节。
Ubiquitin-associated domain-containing protein 1 (UBADC1) is a conserved eukaryotic protein implicated in regulating the ubiquitin-proteasome system (UPS), a critical pathway for protein degradation and cellular homeostasis. It contains a characteristic ubiquitin-associated (UBA) domain, which typically mediates interactions with ubiquitin or ubiquitinated substrates. Human UBADC1. encoded by the *UBADC1* gene on chromosome 5. is a 168-amino acid protein with roles in cell cycle control, DNA damage response, and apoptosis. Studies suggest it binds to the 19S regulatory subunit of the proteasome, potentially modulating substrate recognition or processing. Its interaction with CDC48/p97. a key ATPase in endoplasmic reticulum-associated degradation (ERAD), further links UBADC1 to protein quality control. Dysregulation of UBADC1 has been associated with cancers, neurodegenerative diseases, and immune disorders, highlighting its pathological relevance. Recombinant human UBADC1 protein is typically produced in *E. coli* or mammalian expression systems, enabling functional studies, structural analyses (e.g., crystallography), and screening for molecular interactions. Ongoing research focuses on elucidating its precise molecular mechanisms and therapeutic potential as a drug target.
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