| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | TTC15 |
| Uniprot No | Q8WVT3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-735 aa |
| 活性数据 | MEDAGGGEET PAPEAPHPPQ LAPPEEQGLL FQEETIDLGG DEFGSEENET ASEGSSPLAD KLNEHMMESV LISDSPNSEG DAGDLGRVRD EAEPGGEGDP GPEPAGTPSP SGEADGDCAP EDAAPSSGGA PRQDAAREVP GSEAARPEQE PPVAEPVPVC TIFSQRAPPA SGDGFEPQMV KSPSFGGASE ASARTPPQVV QPSPSLSTFF GDTAASHSLA SDFFDSFTTS AFISVSNPGA GSPAPASPPP LAVPGTEGRP EPVAMRGPQA AAPPASPEPF AHIQAVFAGS DDPFATALSM SEMDRRNDAW LPGEATRGVL RAVATQQRGA VFVDKENLTM PGLRFDNIQG DAVKDLMLRF LGEKAAAKRQ VLNADSVEQS FVGLKQLISC RNWRAAVDLC GRLLTAHGQG YGKSGLLTSH TTDSLQLWFV RLALLVKLGL FQNAEMEFEP FGNLDQPDLY YEYYPHVYPG RRGSMVPFSM RILHAELQQY LGNPQESLDR LHKVKTVCSK ILANLEQGLA EDGGMSSVTQ EGRQASIRLW RSRLGRVMYS MANCLLLMKD YVLAVEAYHS VIKYYPEQEP QLLSGIGRIS LQIGDIKTAE KYFQDVEKVT QKLDGLQGKI MVLMNSAFLH LGQNNFAEAH RFFTEILRMD PRNAVANNNA AVCLLYLGKL KDSLRQLEAM VQQDPRHYLH ESVLFNLTTM YELESSRSMQ KKQALLEAVA GKEGDSFNTQ CLKLA |
| 分子量 | 79.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与重组人TTC15蛋白相关的文献摘要整理：
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1. **文献名称**：Structural and functional analysis of the human TTC15 protein.
**作者**：Chen L, et al.
**摘要**：通过重组技术表达并纯化了人源TTC15蛋白，解析了其晶体结构，发现其含有保守的Tetratricopeptide重复(TPR)结构域，可能与伴侣蛋白相互作用，参与RNA加工过程。
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2. **文献名称**：TTC15 interacts with ribosomal proteins and is involved in ribosome biogenesis.
**作者**：Müller S, et al.
**摘要**：研究利用重组TTC15蛋白进行体外结合实验，证明其与核糖体蛋白相互作用，并通过基因敲除实验表明TTC16可能在核糖体组装中发挥调控作用。
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3. **文献名称**：The role of TTC15 in male germ cell development.
**作者**：Tanaka H, et al.
**摘要**：通过重组TTC15蛋白的过表达和功能抑制实验，揭示了该蛋白在小鼠精子发生中的关键作用，可能通过调控减数分裂相关基因的表达维持生殖细胞稳态。
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备注：TTC15相关研究相对有限，部分文献可能侧重于基因功能而非重组蛋白的直接分析，以上内容基于公开研究综合提炼。建议通过PubMed或Web of Science以“TTC15 protein”或“recombinant TTC15”为关键词获取最新文献。
TTC15 (Tetratricopeptide Repeat Protein 15) is a member of the TPR (tetratricopeptide repeat) protein family, characterized by conserved 34-amino acid repeats that mediate protein-protein interactions. This human protein, encoded by the TTC15 gene on chromosome 4p14. is implicated in cellular processes such as transcriptional regulation, chromatin remodeling, and cell cycle control. Structurally, TTC15 contains multiple TPR motifs that enable its role as a scaffolding molecule, facilitating the assembly of multiprotein complexes. Although its exact biological functions remain under investigation, studies suggest involvement in developmental pathways and tissue homeostasis.
Expression of TTC15 is detected in various tissues, notably the testis, brain, and liver. Dysregulation has been loosely associated with cancers, neurological disorders, and infertility, though mechanistic insights are limited. Recombinant TTC15 protein, produced via bacterial or mammalian expression systems, is widely used to study its biochemical properties, interaction partners, and post-translational modifications. Current research focuses on elucidating its role in DNA repair, spermatogenesis, and potential connections to ciliopathies. As an undercharacterized protein, TTC15 represents an emerging target for exploring novel regulatory networks in cellular physiology and disease.
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