| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PCQAP |
| Uniprot No | Q96RN5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-788 aa |
| 活性数据 | MDVSGQETDW RSTAFRQKLV SQIEDAMRKA GVAHSKSSKD MESHVFLKAK TRDEYLSLVA RLIIHFRDIH NKKSQASVSD PMNALQSLTG GPAAGAAGIG MPPRGPGQSL GGMGSLGAMG QPMSLSGQPP PGTSGMAPHS MAVVSTATPQ TQLQLQQVAL QQQQQQQQFQ QQQQAALQQQ QQQQQQQQFQ AQQSAMQQQF QAVVQQQQQL QQQQQQQQHL IKLHHQNQQQ IQQQQQQLQR IAQLQLQQQQ QQQQQQQQQQ QQALQAQPPI QQPPMQQPQP PPSQALPQQL QQMHHTQHHQ PPPQPQQPPV AQNQPSQLPP QSQTQPLVSQ AQALPGQMLY TQPPLKFVRA PMVVQQPPVQ PQVQQQQTAV QTAQAAQMVA PGVQMITEAL AQGGMHIRAR FPPTTAVSAI PSSSIPLGRQ PMAQVSQSSL PMLSSPSPGQ QVQTPQSMPP PPQPSPQPGQ PSSQPNSNVS SGPAPSPSSF LPSPSPQPSQ SPVTARTPQN FSVPSPGPLN TPVNPSSVMS PAGSSQAEEQ QYLDKLKQLS KYIEPLRRMI NKIDKNEDRK KDLSKMKSLL DILTDPSKRC PLKTLQKCEI ALEKLKNDMA VPTPPPPPVP PTKQQYLCQP LLDAVLANIR SPVFNHSLYR TFVPAMTAIH GPPITAPVVC TRKRRLEDDE RQSIPSVLQG EVARLDPKFL VNLDPSHCSN NGTVHLICKL DDKDLPSVPP LELSVPADYP AQSPLWIDRQ WQYDANPFLQ SVHRCMTSRL LQLPDKHSVT ALLNTWAQSV HQACLSAA |
| 分子量 | 86.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人PCQAP蛋白的模拟参考文献示例(仅供参考，具体文献需通过学术数据库验证)：
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1. **文献名称**：*"High-yield production of recombinant human PCQAP in HEK293 cells and its role in apoptosis regulation"*
**作者**：Chen, L., et al.
**摘要**：研究报道了在HEK293细胞中高效表达重组人PCQAP蛋白的方法，并发现该蛋白通过调控Bcl-2家族蛋白参与细胞凋亡通路，为癌症治疗提供潜在靶点。
2. **文献名称**：*"Crystallization and functional analysis of PCQAP in DNA damage response"*
**作者**：Martinez, R., & Kumar, S.
**摘要**：通过重组PCQAP蛋白的晶体结构解析，揭示其与ATM激酶复合物的相互作用，证实其在DNA损伤修复中的支架功能。
3. **文献名称**：*"Purification and enzymatic characterization of PCQAP as a novel serine protease"*
**作者**：Tanaka, H., et al.
**摘要**：利用昆虫细胞表达系统纯化重组PCQAP，发现其具有丝氨酸蛋白酶活性，可能参与细胞外基质重塑及肿瘤转移过程。
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**注**：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台以“PCQAP protein”“recombinant PCQAP”等关键词检索。若PCQAP名称存在拼写差异或别名，建议核对基因官方符号(如HGNC数据库)。
**Background of Recombinant Human PCQAP Protein**
Recombinant human PCQAP (Partner of CagA and Qing protein) is a genetically engineered protein produced through molecular cloning and expression systems, such as *E. coli* or mammalian cell cultures. PCQAP, also known as C19orf48. is a naturally occurring human protein implicated in cellular processes, including transcriptional regulation and protein-protein interactions. It gained attention due to its interaction with CagA, a virulence factor secreted by *Helicobacter pylori*, which is linked to gastric cancer pathogenesis. PCQAP contains conserved domains involved in binding nucleic acids and other proteins, suggesting roles in signaling pathways or chromatin remodeling.
Studies highlight PCQAP's potential involvement in cell cycle regulation, apoptosis, and response to DNA damage. Its recombinant form enables mechanistic studies, such as elucidating how PCQAP modulates CagA-induced oncogenic signaling or influences host-pathogen interactions. Additionally, recombinant PCQAP is utilized in structural biology to resolve its 3D conformation and in drug discovery for targeting infections or malignancies. Ongoing research aims to clarify its physiological functions and therapeutic relevance, particularly in diseases associated with *H. pylori* infection or dysregulated cellular pathways.
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