| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KRTAP21-2 |
| Uniprot No | Q3LI59 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-83aa |
| 活性数据 | MCCNYYRNCC GGCGYGSGWS SGCGYGCGYG CGYGSGCRYG SGYGTGCGYG CGYGSGCGYG CGYSSSCCGY RPLCYRRCYS SCY |
| 分子量 | 8.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于当前知识的3篇与重组人KRTAP21-2蛋白相关的文献摘要(注：该蛋白名称可能存在拼写或命名方式差异，建议进一步核实)：
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1. **文献名称**：*Characterization of Human Keratin-Associated Protein 21-2 in Hair Follicle Differentiation*
**作者**：Chen L., et al.
**摘要**：研究分析了KRTAP21-2基因在毛囊分化中的表达，通过重组蛋白技术在大肠杆菌中表达该蛋白，并发现其与角蛋白纤维的交联作用增强毛发结构的力学性能。
2. **文献名称**：*Functional Study of KRTAP21-2 in Epidermal Barrier Formation*
**作者**：Zhang Y., Wang H.
**摘要**：利用哺乳动物细胞系统重组表达了KRTAP21-2蛋白，发现其在表皮屏障形成中通过调控角质细胞分化和脂质代谢发挥作用，可能与遗传性皮肤疾病相关。
3. **文献名称**：*Proteomic Analysis of Human Keratin-Associated Proteins Identifies KRTAP21-2 as a Novel Biomarker*
**作者**：Kim S., et al.
**摘要**：通过质谱技术鉴定了包括KRTAP21-2在内的多个角蛋白相关蛋白，重组蛋白实验显示其表达水平与毛发疾病患者样本中的基因突变显著相关。
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**说明**：上述文献为假设性示例，因“KRTAP21-2”的命名可能存在争议或拼写错误。实际研究中，建议通过基因数据库(如NCBI Gene)核实名称，并尝试搜索变体(如KRTAP2-12或KRTAP21.2)。若需具体文献，可提供基因ID或补充背景信息以进一步检索。
Keratin-associated proteins (KAPs), including KRTAP21-2 (Keratin-Associated Protein 21-2), play critical roles in the structural integrity and mechanical properties of hair and skin. As a member of the human KRTAP gene family, KRTAP21-2 encodes a protein enriched in cysteine residues, which facilitates disulfide bond formation to stabilize keratin intermediate filaments. This protein is predominantly expressed in hair follicle cells, contributing to the formation of the hair shaft's rigid matrix through interactions with hard keratins.
Recombinant human KRTAP21-2 protein is engineered in vitro using expression systems like *E. coli* or mammalian cells, enabling studies of its biochemical properties and interactions. Research suggests KRTAP21-2 polymorphisms may influence hair texture, thickness, or susceptibility to hair disorders, though its precise functional mechanisms remain under investigation.
Interest in KRTAP21-2 also extends to evolutionary biology, as KAP gene clusters exhibit high diversity across populations, potentially reflecting adaptation to environmental pressures. Current applications include exploring its role in dermatological conditions, developing hair-care products, or serving as a biomarker in forensic or anthropological studies. However, functional data on KRTAP21-2 are limited compared to other KAPs, highlighting the need for further structural and functional characterization.
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