| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | KRTAP17-1 |
| Uniprot No | Q9BYP8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-105aa |
| 活性数据 | MGCCPGDCFTCCTQEQNCCEECCCQPGCCGCCGSCCGCGGSGCGGSGCGGSCCGSSCCGSGCGGCGGCGGCGGGCCGSSCCGSSCCGSGCCGPVCCQPTPICDTK |
| 分子量 | 38.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人KRTAP17-1蛋白的公开研究较为有限，以下为基于相关领域文献的推测性示例(仅供参考，需通过学术数据库验证)：
1. **"Characterization of the human KRTAP17-1 gene and its encoded protein"**
- *作者：Smith A, et al.*
- 摘要：本研究首次克隆并表达了重组人KRTAP17-1蛋白，发现其在毛囊角质细胞中特异性表达，可能与毛发结构稳定性相关，为研究遗传性毛发疾病提供分子基础。
2. **"Functional analysis of recombinant KRTAP17-1 in keratin assembly"**
- *作者：Zhang L, et al.*
- 摘要：通过体外重组表达KRTAP17-1蛋白，证实其与角蛋白K35/K85相互作用，影响细胞骨架网络形成，提示其在表皮分化中的潜在调控作用。
3. **"Polymorphisms in KRTAP17-1 and their association with wool traits in mammals"**
- *作者：Wang Y, et al.*
- 摘要：通过基因测序和重组蛋白功能实验，发现KRTAP17-1基因多态性与毛发纤维直径相关，为农业动物育种提供了分子标记参考。
4. **"Expression and purification of recombinant human KRTAP17-1 in E. coli"**
- *作者：Kim S, et al.*
- 摘要：优化了KRTAP17-1蛋白的大肠杆菌表达系统，并验证其溶解性和稳定性，为后续抗体开发及结构研究奠定技术基础。
**注意事项**：
- 以上文献为模拟示例，实际研究需通过**PubMed/Google Scholar**检索关键词如“KRTAP17-1 recombinant”、“keratin-associated protein 17-1”等获取。
- 该蛋白研究可能更多集中于动物模型(如绵羊毛囊)，建议扩展检索范围至相关物种。
Recombinant human KRTAP17-1 protein is a genetically engineered variant of the keratin-associated protein 17-1 (KRTAP17-1), a member of the keratin-associated protein (KAP) family. These proteins play critical roles in forming the structural matrix of hair and nails by interacting with keratin intermediate filaments. KRTAP17-1 is encoded by the *KRTAP17-1* gene located on human chromosome 17q21.2. within a cluster of genes regulating hair shaft composition and mechanical properties. It is predominantly expressed in the hair follicle, where it contributes to disulfide bond crosslinking, influencing hair texture, strength, and elasticity. Variations in KRTAP genes are associated with diverse hair phenotypes and certain genetic disorders.
Recombinant KRTAP17-1 is produced in heterologous expression systems (e.g., *E. coli* or mammalian cells) to study its biochemical properties, molecular interactions, and potential applications. Its production enables research into hair biology, including disorders like trichothiodystrophy or alopecia, and the development of cosmetic or therapeutic interventions. Furthermore, it serves as a tool to explore post-translational modifications, aggregation mechanisms, and its role in epithelial tissue integrity. Standardized recombinant proteins also support antibody development for diagnostic purposes. Ongoing studies aim to clarify its exact functional role in keratin networks and its tissue-specific regulation.
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