| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM55A |
| Uniprot No | Q8N323 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-405aa |
| 氨基酸序列 | MSSPALTAGASGKVMDFNNGTYLVSFTLFWEGQVSLSLLLIHPSEGASALWRARNQGYDKIIFKGKFVNGTSHVFTECGLTLNSNAELCEYLDDRDQEAFYCMKPQHMPCEALTYMTTRNREVSYLTDKENSLFHRSKVGVEMMKDRKHIDVTNCNKREKIEETCQVGMKPPVPGGYTLQGKWITTFCNQVQLDTIKINGCLKGKLIYLLGDSTLRQWIYYFPKVVKTLKFFDLHETGIFKKHLLLDAERHTQIQWKKHSYPFVTFQLYSLIDHDYIPREIDRLSGDKNTAIVITFGQHFRPFPIDIFIRRAIGVQKAIERLFLRSPATKVIIKTENIREMHIETERFVDFHGYIHYLIMKDIFKDLNVGIIDAWDMTIAYGTDTIHPPDHVIGNQINMFLNYIC |
| 分子量 | 73.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是模拟的关于重组人FAM55A蛋白研究的参考文献示例(实际文献需通过学术数据库检索确认)：
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1. **文献名称**: "FAM55A modulates neuronal differentiation through interaction with PI3K signaling"
**作者**: Yamaguchi H. et al. (2020)
**摘要**: 研究揭示FAM55A蛋白通过激活PI3K/AKT通路促进神经干细胞分化为成熟神经元，重组人FAM55A在体外实验中显著增强神经突触生长。
2. **文献名称**: "Functional characterization of FAM55A in cancer cell proliferation"
**作者**: Sato M. et al. (2018)
**摘要**: 发现FAM55A过表达与结肠癌细胞增殖相关，重组蛋白处理可上调Wnt/β-catenin通路基因，提示其可能作为癌症治疗的潜在靶点。
3. **文献名称**: "Structural analysis of human FAM55A and its lipid-binding properties"
**作者**: Kwon J. et al. (2019)
**摘要**: 通过X射线晶体学解析FAM55A的C端结构域，发现其能够结合磷脂分子，重组蛋白在细胞膜修复过程中可能发挥脂质转运功能。
4. **文献名称**: "FAM55A as a novel regulator of insulin sensitivity in adipose tissue"
**作者**: Chen L. et al. (2021)
**摘要**: 研究表明，重组人FAM55A蛋白通过调节脂肪细胞中IRS-1的磷酸化水平改善胰岛素抵抗，为代谢综合征提供潜在干预策略。
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**注意**：以上为模拟内容，实际研究中FAM55A相关文献较少，建议通过PubMed或Google Scholar使用关键词“FAM55A protein”、“recombinant FAM55A”等检索最新文献。
**Background of Recombinant Human FAM55A Protein**
Recombinant human FAM55A (family with sequence similarity 55 member A) is a protein encoded by the *FAM55A* gene, located on chromosome X. Though its biological functions remain incompletely characterized, FAM55A is speculated to play roles in cellular signaling, proliferation, or differentiation, potentially linked to its predicted structural domains, including a conserved phospholipase-like motif. Emerging studies suggest its involvement in cancer progression and neurological processes, with altered expression observed in certain tumors and neural tissues.
The recombinant form of FAM55A is typically produced via heterologous expression systems (e.g., *E. coli* or mammalian cells) to enable functional studies. Its production allows researchers to investigate protein-protein interactions, enzymatic activities, and regulatory pathways in vitro or in vivo. Despite limited data, FAM55A is postulated to interact with cytoskeletal components or signaling molecules, hinting at roles in cell motility or survival.
Interest in recombinant FAM55A also stems from its potential as a biomarker or therapeutic target, particularly in cancers where its dysregulation correlates with clinical outcomes. However, mechanistic insights remain sparse, emphasizing the need for further structural and functional exploration. Current research focuses on clarifying its molecular interactions and validating its physiological relevance, bridging gaps in understanding its contribution to human health and disease.
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