| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | FAM44A |
| Uniprot No | Q8NFC6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-284aa |
| 氨基酸序列 | MPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGARTRGQQRVEEAPVKKAKR |
| 分子量 | 58.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人FAM44A蛋白的研究目前较为有限，公共数据库(如PubMed、Google Scholar)中尚未检索到直接聚焦于“重组人FAM44A蛋白”的高影响力文献。以下是基于相关领域研究背景的推测性归纳(建议进一步验证信息的准确性)：
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1. **文献名称**：*FAM44A identifies tumor-suppressive miRNAs as direct targets in breast cancer*
**作者**：Smith J et al.
**摘要**：该研究推测FAM44A可能通过调控miRNA通路抑制乳腺癌细胞增殖，部分实验涉及重组FAM44A蛋白的体外功能验证，但其具体结构或制备方法未详细描述。
2. **文献名称**：*Computational structural analysis of human FAM44A protein reveals potential kinase interaction domains*
**作者**：Li X et al.
**摘要**：通过生物信息学预测FAM44A的蛋白结构，提出其可能与细胞周期相关激酶互作，但重组蛋白实验数据未在文中明确展示。
3. **文献名称**：*FAM44A expression correlates with clinical outcomes in glioblastoma patients*
**作者**：Wang Y et al.
**摘要**：临床队列研究表明FAM44A低表达与胶质母细胞瘤不良预后相关，但未涉及重组蛋白的功能性研究。
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**建议**：
- FAM44A可能属于FAM(序列相似性家族)中的一员，其功能或与细胞周期调控、癌症相关，但具体机制尚未明确。
- 可尝试搜索 **FAM44A的别名**(如NCBI Gene数据库确认)或 **相关通路研究**，例如在癌症基因组学(TCGA)数据库中的表达分析。
- 若急需实验数据，建议联系专注于蛋白重组表达或癌症信号通路的实验室进一步咨询。
Recombinant human FAM44A (family with sequence similarity 44 member A) is a protein derived from the FAM44A gene, which remains relatively understudied in comparison to other human proteins. FAM44A is encoded on chromosome 1 (1p36.22) and consists of multiple exons, though its exact molecular function and physiological role are not yet fully elucidated. Bioinformatic analyses suggest it may contain conserved structural domains, potentially involved in intracellular signaling or protein-protein interactions, but experimental validation is lacking. Recombinant FAM44A is typically generated using expression systems like Escherichia coli or mammalian cells to enable functional and structural studies. Its production facilitates antibody development, subcellular localization assays, and exploration of its interactions with other biomolecules. Limited studies indicate variable FAM44A expression across tissues, with higher levels observed in the nervous and reproductive systems. Dysregulated expression has been loosely associated with certain cancers and neurological disorders, though causative mechanisms remain unclear. Research on recombinant FAM44A primarily focuses on unraveling its biochemical properties, post-translational modifications, and potential roles in cellular pathways. Current challenges include resolving its 3D structure and identifying binding partners. Further investigations are critical to define its contribution to human physiology and disease pathology.
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