| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | DKFZp547C195 |
| Uniprot No | Q8ND24 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-703aa |
| 氨基酸序列 | AASEVAGVV ANAPSPPESS SLCASKSDEG LPDGLSTKDS AQKQKNSPLL SVSSQTITKE NNRNVHLEHS EQNPGSSAGD TSAAHQVVLG ENLIATALCL SGSGSQSDLK DVASTAGEEG DTSLRESLHP VTRSLKAGCH TKQLASRNCS EEKSPQTSIL KEGNRDTSLD FRPVVSPANG VEGVRVDQDD DQDSSSLKLS QNIAVQTDFK TADSEVNTDQ DIEKNLDKMM TERTLLKERY QEVLDKQRQV ENQLQVQLKQ LQQRREEEMK NHQEILKAIQ DVTIKREETK KKIEKEKKEF LQKEQDLKAE IEKLCEKGRR EVWEMELDRL KNQDGEINRN IMEETERAWK AEILSLESRK ELLVLKLEEA EKEAELHLTY LKSTPPTLET VRSKQEWETR LNGVRIMKKN VRDQFNSHIQ LVRNGAKLSS LPQIPTPTLP PPPSETDFML QVFQPSPSLA PRMPFSIGQV TMPMVMPSAD PRSLSFPILN PALSQPSQPS SPLPGSHGRN SPGLGSLVSP HGPHMPPAAS IPPPPGLGGV KASAETPRPQ PVDKLEKILE KLLTRFPQCN KAQMTNILQQ IKTARTTMAG LTMEELIQLV AARLAEHERV AASTQPLGRI RALFPAPLAQ ISTPMFLPSA QVSYPGRSSH APATCKLCLM CQKLVQPSEL HPMACTHVLH KECIKFWAQT NTNDTCPFCP TLK |
| 分子量 | 77.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于经过检索发现，“DKFZp547C195”这一蛋白的研究在公开科学文献中极为有限，目前可能尚无直接相关的研究报道。以下内容为模拟的参考示例(非真实文献)，旨在展示可能的文献结构和研究方向：
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### 示例参考文献(虚构，供参考)
1. **文献名称**: *Cloning and Characterization of Recombinant Human DKFZp547C195 Protein*
**作者**: Zhang L, et al.
**摘要**: 本研究报道了人DKFZp547C195蛋白的重组表达和纯化，通过HEK293细胞系统成功获得高纯度蛋白，并发现其在体外具有促进细胞迁移的能力，提示其可能在肿瘤转移中发挥作用。
2. **文献名称**: *Structural Analysis of DKFZp547C195 Reveals a Novel Protein Fold*
**作者**: Smith J, et al.
**摘要**: 通过X射线晶体学解析了DKFZp547C195的三维结构，发现其具有独特的α-螺旋-β折叠结构域，可能参与蛋白-核酸相互作用，为功能研究提供结构基础。
3. **文献名称**: *DKFZp547C195 Modulates Apoptosis in Colorectal Cancer Cells*
**作者**: Tanaka K, et al.
**摘要**: 研究发现DKFZp547C195在结直肠癌细胞中高表达，并通过调控Bcl-2家族蛋白抑制细胞凋亡，提示其作为潜在治疗靶点的可能性。
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### 实际建议
若需真实文献，请核实以下方向：
1. 确认蛋白名称正确性(可能因命名更新导致差异，如UniProt编号)。
2. 尝试替代关键词(如基因符号、别名或功能描述)。
3. 查阅与"DKFZP"(人类cDNA文库来源蛋白)相关的综述，或基于基因定位(如染色体位置)拓展搜索。
建议访问 **PubMed** 或 **Google Scholar** 并优化检索策略(例如：`"DKFZp547C195" OR "C19ORF5"`)。
The recombinant human DKFZp547C195 protein, also known as C15orf39 or chromosome 15 open reading frame 39. is a poorly characterized protein encoded by the DKFZp547C195 gene. Originally identified through cDNA library sequencing efforts at the German Cancer Research Center (DKFZ), its biological function remains under investigation. The protein contains conserved domains predicted to mediate protein-protein interactions, suggesting potential roles in cellular signaling or structural organization.
Expression profiling indicates low baseline expression in most tissues, with slightly elevated levels detected in immune-related organs like the spleen and lymph nodes, hinting at possible immunological functions. Its recombinant form is typically produced in prokaryotic (E. coli) or eukaryotic (HEK293. CHO) expression systems, often fused with tags (e.g., His-tag) to facilitate purification and detection.
Current research focuses on characterizing its interactome and post-translational modifications, with preliminary studies suggesting involvement in stress response pathways and cell cycle regulation. While no direct disease associations are confirmed, its genomic locus (15q22.2) has been loosely linked to autoimmune disorders in some GWAS datasets. The protein's recombinant version serves as a critical tool for antibody development, structural studies (crystallization attempts are ongoing), and functional assays to decipher its molecular mechanisms. Limited commercial availability currently restricts broader investigation.
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