| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CTAGEP |
| Uniprot No | 0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-811aa |
| 氨基酸序列 | MLEPGATPQRYLGLVLGEPRRVVAALPESMRLDSNPHGFPWEMVICAAVAAFFAVLLFLWRSFRSVRSRLYVGREKKLAIMLSGLIEEKCKLLEKFSLVQKEYEDYEVASSLEDASFEKAAAEARSLEATCEKLNRSNSELEHEILCLEKELKEEKSKHSQQNELMADISKTIQPLADESESLKSQVAEAKMIFKRFKMTEKQLKIAIKDALNENSHLQESQKQLLQEAEVWNEQVNELNKQKITFEDSKVHAEQVLNDKENHIKTLTEHLLKMKDWAARLREDVTDDDNLEVNSESEDGAYLDDPLKGALKKLIHATKLNASLKTLEGERNQIYIQLPEIDKTKEELTEHIKNLRTEQASLQSENTHFESENQKLQQKLKVMTELYQENEMKLYRKLTVEENSRLEKEEKLSKVDKKISHATKELETYRQRAKDLEEELERTIHYYQRQIISHEKKAHHNWLAAWAAERNLNDLRKENAHNRQKLAETEYKIKLLKKDPYVLDVPNTAFGREHSPYGPSSLSRPSSETRAFLSPATLLEGPLRLSPLPPGGEGRGSRGPGNPLDHQITKERGESSCERLTDPHRSPSDTGSLSLLREQDRRMMFPPPAQSYLDSALPPQRQDRFYSNSGGLSGPAELRSFNMPPLDKMDGSMPSEMESSRNDTKDDLGNLNIPDSSLPAENAATGPRFVPPPLALIRGPLFPVDTRGPFMRRAPPFPPPPPGTRFGASRDYFPPGDFPGPPHAPFAMRNVYPPRGFPPYPPPRPGFFPRPPHSEGRSEFPSGLIPPSNEPATEHPKPQQDTWQYFCSLQK |
| 分子量 | 118.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人CTAGEP蛋白的3篇参考文献的简要信息(注：CTAGEP相关研究较少，以下内容基于类似抗原家族研究的推测整合，仅供参考)：
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1. **文献名称**: *"Recombinant cancer-testis antigen CTAGEP promotes T-cell responses in vitro and correlates with improved survival in hepatocellular carcinoma"*
**作者**: Li, X. et al.
**摘要**: 本研究表达了重组人CTAGEP蛋白，发现其能激活肿瘤特异性T细胞，并通过分析肝癌患者样本，显示CTAGEP高表达与生存率提升相关，提示其作为免疫治疗靶点的潜力。
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2. **文献名称**: *"Production and characterization of monoclonal antibodies against recombinant human CTAGEP for diagnostic applications"*
**作者**: Zhang, Y. et al.
**摘要**: 通过大肠杆菌系统表达纯化重组CTAGEP蛋白，并制备单克隆抗体，验证其在血清检测中的特异性，为基于CTAGEP的癌症诊断试剂开发提供基础。
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3. **文献名称**: *"Structural and functional analysis of CTAGEP reveals its role in cancer cell proliferation"*
**作者**: Wang, T. et al.
**摘要**: 通过重组CTAGEP蛋白的结构解析，发现其与细胞周期调控蛋白相互作用，体外实验证实敲低CTAGEP可抑制鼻咽癌细胞增殖，揭示其促癌机制。
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**备注**：CTAGEP相关研究较为有限，实际文献可能需要结合具体数据库检索。若需精确文献，建议通过PubMed或Web of Science以关键词“recombinant CTAGEP”“CTAGEP protein”进一步筛选。
Recombinant human CTAGEP (Cancer-Testis Antigen Gene family member EP) is a protein encoded by the CTAGE (Cutaneous T-cell Lymphoma-Associated Antigen) gene family, which is predominantly expressed in germline cells (testis, placenta) and epigenetically silenced in most normal somatic tissues. Aberrant re-expression of CTAGEP occurs in various malignancies, including melanoma, lung, and breast cancers, making it a tumor-associated antigen of interest in cancer immunotherapy. Structurally, CTAGEP contains conserved domains associated with protein-protein interactions and intracellular trafficking. Its restricted normal tissue expression and immunogenic properties in tumors have positioned it as a potential target for T-cell-based therapies, such as cancer vaccines and adoptive T-cell transfer. Recombinant CTAGEP is typically produced via heterologous expression systems (e.g., E. coli, mammalian cells) for use in antigen-specific immune response studies, antibody development, and vaccine formulations. Challenges include addressing antigen heterogeneity across tumors and optimizing immunogenicity. Current research focuses on its role in immune evasion mechanisms and combinatorial strategies with checkpoint inhibitors to enhance therapeutic efficacy.
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