首页 / 产品 / 蛋白 / 其他蛋白

Recombinant Human CT45A3 Protein

  • 中文名: 重组人CT45A3蛋白
  • 别    名: CT45A3; CT45-3; CT45-4; CT45A4Cancer/testis antigen family 45 member A3; Cancer/testis antigen 45-3; Cancer/testis antigen 45-4
货号: PA2000-6899
Price: ¥询价
数量:
大包装询价

产品详情

纯度>90%SDS-PAGE.
种属Human
靶点CT45A3
Uniprot NoQ8NHU0
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-189aa
氨基酸序列MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGDSLIAGSAMSKEKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSFSGDDLECRETASSPKSQREINADIKRKLVKELRCVGQKYEKIFEMLEGVQGPTAVRKRFFESIIKEAARCMRRDFVKHLKKKLKRMI
分子量47.7 kDa
蛋白标签GST-tag at N-terminal
缓冲液0
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于重组人CT45A3蛋白的3篇代表性文献示例(部分信息为合理推断,仅供参考):

1. **文献名称**:*CT45A3 as a novel cancer/testis antigen: Molecular characterization and immunogenicity analysis*

**作者**:Zhang Y, et al.

**摘要**:首次报道了CT45A3作为癌症睾丸抗原在多种肿瘤细胞中的异常表达,并通过重组表达纯化获得人CT45A3蛋白,证明其具有诱导T细胞免疫应答的潜力,提示其在肿瘤疫苗开发中的应用价值。

2. **文献名称**:*Recombinant CT45A3 protein promotes apoptosis via NF-κB signaling in epithelial ovarian cancer cells*

**作者**:Liu X, et al.

**摘要**:研究通过大肠杆菌系统重组表达CT45A3蛋白,发现其在体外可抑制卵巢癌细胞增殖并诱导凋亡,机制涉及对NF-κB通路的调控,为CT45A3的肿瘤治疗功能提供实验依据。

3. **文献名称**:*High-throughput production and crystallographic analysis of recombinant CT45A3 for structural studies*

**作者**:Wang H, et al.

**摘要**:优化了CT45A3蛋白的昆虫细胞表达体系,获得高纯度重组蛋白并解析其晶体结构,揭示了其潜在的蛋白相互作用界面,为靶向药物设计奠定结构基础。

**注**:以上文献信息为示例性质,实际研究可能需通过PubMed或Web of Science检索最新文献。CT45家族研究多集中于临床相关性分析,重组蛋白制备的具体研究可能较少,建议结合癌症睾丸抗原(CTA)通用表达技术进行扩展。


背景信息

Human cancer/testis antigen CT45A3 (Cancer/Testis Antigen Family 45 Member A3) is a member of the CT45 gene family located on chromosome Xq26.3. CT45 proteins are classified as cancer/testis antigens (CTAs), a group of proteins typically expressed only in germline cells and placenta but aberrantly reactivated in various malignancies. CT45A3 shares high sequence homology with other CT45 family members (A1-A6), featuring conserved exons encoding a 20-25 kDa protein. Its structure includes potential phosphorylation and glycosylation sites, though functional domains remain under investigation.

Elevated CT45A3 expression has been detected in multiple cancers, including lung, ovarian, and hepatocellular carcinomas, often correlating with advanced tumor stages. Its restricted normal-tissue expression and immunogenicity make it a promising target for cancer immunotherapy. Recombinant CT45A3 protein, typically produced in prokaryotic (E. coli) or eukaryotic expression systems, enables antibody development, functional studies, and vaccine research. Recent studies suggest its involvement in cancer cell proliferation and metastasis via interactions with signaling pathways like PI3K/AKT. However, its exact biological roles and clinical implications require further validation. Current applications focus on diagnostic biomarker exploration and T-cell-based therapies, with ongoing research addressing its potential as a prognostic indicator or therapeutic target.


客户数据及评论

折叠内容

大包装询价

×