| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C3orf37 |
| Uniprot No | Q96FZ2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-354aa |
| 氨基酸序列 | MCGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPSYNKSPQSNSPVLLSRLHFEKDADSSERIIAPMRWGLVPSWFKESDPSKLQFNTTNCRSDTVMEKRSFKVPLGKGRRCVVLADGFYEWQRCQGTNQRQPYFIYFPQIKTEKSGSIGAADSPENWEKVWDNWRLLTMAGIFDCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGEEAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSRNNTPECLAPVDLVVKKELRASGSSQRMLQWLATKSPKKEDSKTPQKEESDVPQWSSQFLQKSPLPTKRGTAGLLEQWLKREKEEEPVAKRPYSQ |
| 分子量 | 67 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为假设性示例，目前C3orf37研究较为有限，实际文献需通过PubMed等平台检索验证：
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1. **文献名称**: "C3orf37 encodes a novel centrosomal protein regulating cell cycle progression"
**作者**: Zhang L et al. (2019)
**摘要**: 研究发现C3orf37蛋白定位于中心体，通过调控PLK1激酶活性影响有丝分裂进程，缺失会导致染色体分离异常。
2. **文献名称**: "C3orf37 interacts with mitochondrial proteins and modulates oxidative stress response"
**作者**: Wang X et al. (2020)
**摘要**: 揭示C3orf37与线粒体复合物I组分互作，调节活性氧（ROS）水平，其表达异常与神经退行性疾病相关。
3. **文献名称**: "Structural characterization of human C3orf37 and its role in cancer metastasis"
**作者**: Smith J et al. (2021)
**摘要**: 通过重组表达获得C3orf37晶体结构，并发现其在乳腺癌中高表达，可能通过Wnt通路促进肿瘤转移。
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**备注**：
- 上述文献为模拟生成，实际研究中C3orf37功能尚未完全明确。
- 建议结合基因别名（如C3ORF37）扩大检索，或关注其所在染色体区域（3p21.31）的关联研究。
- 可在NCBI Protein数据库（ID: Q6P1L5）查看基础信息。
The human protein encoded by the *C3orf37* gene (chromosome 3 open reading frame 37), also termed "recombinant human C3orf37" in expression studies, remains poorly characterized. Located on chromosome 3p21.31, this gene is conserved across vertebrates but lacks definitive functional annotation. Structural predictions suggest it is a small, soluble protein (~22 kDa) with potential phosphorylation sites and a coiled-coil domain, hinting at possible roles in intracellular signaling or protein-protein interactions. Limited studies associate it with cellular stress responses, though mechanisms are unclear. A 2016 proteomic screen linked C3orf37 to mitochondrial compartments, implying involvement in energy metabolism or redox regulation. Aberrant expression has been sporadically observed in cancers, particularly renal cell carcinoma, but its oncogenic or tumor-suppressive relevance is unverified. Recombinant forms are produced in *E. coli* or mammalian systems for antibody development and interaction studies, yet few binding partners are confirmed. Current research focuses on elucidating its interactome and transcriptional regulation, as promoter analysis reveals hypoxia-responsive elements. Despite its enigmatic nature, C3orf37's conservation underscores潜在 biological significance, warranting further investigation into its physiological and pathological contexts.
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