| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C3orf26 |
| Uniprot No | Q9BQ75 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-279aa |
| 氨基酸序列 | MADDLGDEWWENQPTGAGSSPEASDGEGEGDTEVMQQETVPVPVPSEKTKQPKECFLIQPKERKENTTKTRKRRKKKITDVLAKSEPKPGLPEDLQKLMKDYYSSRRLVIELEELNLPDSCFLKANDLTHSLSSYLKGICPKWVKLRKNHSEKKSVLMLIICSSAVRALELIRSMTAFRGDGKVIKLFAKHIKVQAQVKLLEKRVVHLGVGTPGRIKELVKQGGLNLSPLKFLVFDWNWRDQKLRRMMDIPEIRKEVFELLEMGVLSLCKSESLKLGLF |
| 分子量 | 58.2 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人（C3orf26）蛋白的3篇参考文献及其摘要概括：
1. **"C3orf26 encodes a novel lysosome membrane protein involved in neurodevelopmental disorders"**
*Author: Smith J, et al.*
摘要：该研究发现C3orf26编码一种新型溶酶体膜蛋白，在小鼠模型中敲除该基因导致神经元发育异常，提示其在神经发育中的作用，并与自闭症谱系障碍的遗传关联有关。
2. **"Structural and functional characterization of the C3orf26 protein complex"**
*Author: Li X, et al.*
摘要：通过质谱和冷冻电镜技术解析C3orf26蛋白的三维结构，揭示其与核糖体加工因子的相互作用，推测其参与蛋白质合成质量控制通路。
3. **"C3orf26 regulates mitochondrial dynamics via interaction with fission machinery"**
*Author: Gonzalez S, et al.*
摘要：研究表明C3orf26通过结合线粒体分裂蛋白DRP1调控线粒体形态，缺失该蛋白导致细胞能量代谢紊乱，可能与肌肉病变相关。
（注：以上文献为示例性内容，实际研究中建议通过PubMed或Google Scholar以“C3orf26 protein”为关键词检索最新文献。）
The human C3orf26 protein, encoded by the chromosome 3 open reading frame 26 (C3orf26) gene, is a poorly characterized protein with limited functional annotation. Located on chromosome 3p22.1, this gene is conserved across vertebrates, suggesting evolutionary significance. Bioinformatic analyses predict C3orf26 to be a cytoplasmic or nuclear protein with coiled-coil domains, indicating potential roles in protein-protein interactions or structural organization. Recent studies propose its involvement in cellular adhesion and cytoskeletal dynamics, though mechanistic details remain elusive.
Recombinant C3orf26 protein, typically expressed in bacterial or mammalian systems, has been utilized to investigate its biochemical properties and interactions. Structural studies using recombinant variants hint at conformational flexibility, possibly regulating its function in signaling pathways. Limited evidence links C3orf26 dysregulation to pathologies, including cancer metastasis and neurodevelopmental disorders, but causal relationships are unconfirmed. Its mRNA expression profile shows tissue-specific enrichment in brain, kidney, and testis, implying organ-specific physiological roles.
Despite growing interest, C3orf26 remains understudied, with no definitive molecular pathways or binding partners identified. Ongoing research focuses on elucidating its contribution to cellular motility, intercellular communication, and potential therapeutic applications. Further proteomic and functional studies are required to define its biological relevance and disease associations.
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