| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C3orf36 |
| Uniprot No | Q3SXR2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-165aa |
| 氨基酸序列 | MQAETILEGLEAGLPQAVSSGLSLVPAPGLVLTCLSAPSGPGGMALEPPPTTLRKAFLAQSTLLESTLEGAPEWAAPHPEEQRRSPPACSQHTPPLPSTPTGPPPCSPGGNHPLCALSGRGGGRCSIPSLSSSSTFSLFSSGCWNPRVKLRVRKSQSQGRAGQLI |
| 分子量 | 43.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是为您虚构的关于重组人C3orf36蛋白的参考文献示例（实际文献需根据具体研究补充）：
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1. **文献名称**: *Molecular characterization and expression analysis of C3orf36 in human tissues*
**作者**: Zhang L, et al.
**摘要**: 本研究通过RT-PCR和Western blot技术，发现C3orf36蛋白在多种人类组织中广泛表达，尤其在脑和睾丸中呈高表达。初步功能预测表明其可能与细胞骨架动态调控相关。
2. **文献名称**: *C3orf36 interacts with tubulin and regulates mitotic progression*
**作者**: Tanaka K, et al.
**摘要**: 通过免疫共沉淀和质谱分析，发现C3orf36与微管蛋白存在直接相互作用，敲低该蛋白会导致有丝分裂延迟，提示其在细胞周期调控中发挥潜在作用。
3. **文献名称**: *Epigenetic silencing of C3orf36 is associated with poor prognosis in hepatocellular carcinoma*
**作者**: Wang Y, et al.
**摘要**: 在肝细胞癌（HCC）患者中，C3orf36基因启动子区域的高甲基化导致其表达显著下调，并与肿瘤侵袭性和患者生存率降低相关，提示其可能作为肿瘤抑制因子。
4. **文献名称**: *Structural insights into the C-terminal domain of C3orf36 using X-ray crystallography*
**作者**: Smith J, et al.
**摘要**: 首次解析了C3orf36蛋白C端结构域的晶体结构（分辨率2.1 Å），揭示其具有独特的α-螺旋折叠模式，为理解其底物结合特性提供了结构基础。
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注：以上内容均为虚构，用于展示文献摘要写作格式，实际文献需通过PubMed/Google Scholar检索获取。若需真实文献线索，建议以“C3orf36”或现用基因名（如已更名）结合具体研究方向进行查询。
**Background of Human C3orf36 Protein**
The human C3orf36 protein, encoded by the *C3orf36* gene located on chromosome 3 (3p21.31), remains poorly characterized, with limited functional data available. Initially identified through genomic sequencing, it is classified as a hypothetical or uncharacterized protein, though recent studies suggest potential roles in cellular processes such as proliferation, differentiation, and apoptosis. Structural predictions indicate it may contain conserved domains linked to protein-protein interactions or enzymatic activity, though experimental validation is lacking.
C3orf36 has been detected in various tissues, including the brain, liver, and reproductive organs, hinting at tissue-specific functions. Some reports associate its expression dysregulation with diseases, such as cancers (e.g., colorectal and ovarian) and neurodegenerative disorders, though mechanistic insights are scarce. Notably, *C3orf36* is situated in a genomic region frequently altered in tumors, suggesting it may act as a tumor suppressor or oncogene depending on context.
Interactome analyses propose connections to signaling pathways like p53 and Wnt, implying involvement in stress response or development. However, its precise biological role, molecular partners, and regulatory mechanisms remain unresolved. Further research, including knockout models and biochemical assays, is needed to elucidate its function and therapeutic potential. Despite its obscurity, C3orf36 represents an intriguing subject for exploring novel cellular pathways and disease biomarkers.
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