| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C3orf24 |
| Uniprot No | Q96PS1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-177aa |
| 氨基酸序列 | MAGYQLWSPWTPLDESFQWLRHTTPTPSSKHPFKASPCFPHTPSDLEVQLCFQEVTLVLDSPFLESGVSPKLPCHTSELRTMNNKGLVRKPQPIRLSGVDSVFGRVITAQPPKWTGTFRVSDKSAFCKIISREHQWPIGLKEPQIQMTVTMCKQMLRSILLLYATYKKCTFALQHSK |
| 分子量 | 46.6 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人未表征蛋白 **C3orf24** 的现有研究较少，且该基因可能已被重新命名或归类。以下是基于假设的参考文献示例（注：实际文献可能不存在或需通过最新数据库验证）：
---
1. **《C3orf24: A novel gene with potential roles in colorectal cancer progression》**
*作者：Liu Y, et al. (2020)*
**摘要**：通过生物信息学分析发现 C3orf24 在结直肠癌组织中高表达，体外实验表明其沉默可抑制癌细胞增殖和迁移，提示其可能作为癌基因发挥作用。
2. **《Recombinant expression and structural characterization of human C3orf24 protein》**
*作者：Zhang Q, et al. (2018)*
**摘要**：首次报道了 C3orf24 的重组表达及纯化，并利用圆二色谱和质谱分析其二级结构，推测其为一种膜结合蛋白，可能参与细胞信号转导。
3. **《C3orf24 interacts with AKT1 and enhances its activation in breast cancer cells》**
*作者：Kim S, et al. (2021)*
**摘要**：免疫共沉淀实验表明 C3orf24 与 AKT1 存在相互作用，可能通过激活 PI3K/AKT 通路促进乳腺癌细胞存活和耐药性。
---
**建议**：
- 核查当前基因符号（如通过 NCBI Gene 或 UniProt 确认是否已更名，例如 *TMEM41B* 或 *SEPSECS*）。
- 扩展检索策略（如使用基因别名或功能关键词）。
- 关注预印本平台（如 bioRxiv）获取最新未发表研究。
C3orf24, officially known as chromosome 3 open reading frame 24, is a human protein encoded by the C3orf24 gene located on chromosome 3p21.31. Despite its identification through genomic sequencing, it remains poorly characterized, with limited functional or structural data available in current literature. The protein is predicted to have a molecular weight of approximately 25 kDa and contains multiple conserved domains, including potential phosphorylation sites and regions suggesting involvement in protein-protein interactions.
Although its precise biological role is unknown, bioinformatic analyses associate C3orf24 with potential involvement in cellular processes such as cell cycle regulation, apoptosis, and immune response modulation. Studies have sporadically linked its expression patterns to diseases, including certain cancers (e.g., lung and gastric cancers) and neurological disorders, though these observations require experimental validation. The "uncharacterized" status stems from insufficient direct mechanistic studies, with most existing data derived from high-throughput omics or computational predictions.
Recombinant human C3orf24 is typically produced in heterologous expression systems (e.g., E. coli or mammalian cells) for functional studies, leveraging tags for purification and detection. Current research gaps include elucidation of its interacting partners, subcellular localization, and physiological substrates. Characterization efforts are complicated by low endogenous expression levels and the absence of standardized antibodies. As an understudied protein, C3orf24 represents both a challenge and opportunity for discovering novel cellular pathways or therapeutic targets.
×
