| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf78 |
| Uniprot No | Q86XK3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-245aa |
| 氨基酸序列 | MAEGEKNQDFTFKMESPSDSAVVLPSTPQASANPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVESEENDQTFSEKPASSTEENCLEFQESFKHIDSEFEENTNLKNTLKNLNVCESQSLDSGSCSALQNEFVSEKLPKQRLNAEKAKLVKQVQEKEDLLRRLKLVKMYRSKNDLSQLQLLIKKWRSCSQLLLYELQSAVSEENKKLSLTQLIDHYGLDDKLLHYNRSEEEFIDV |
| 分子量 | 54.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C10orf78蛋白的假设性参考文献示例(注：由于C10orf78研究可能有限，以下内容仅为推测性示例，真实文献需通过学术数据库验证)：
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1. **文献名称**: "Structural characterization of the recombinant human C10orf78 protein and its role in mitochondrial dynamics"
**作者**: Li X, Wang Y, et al.
**摘要**: 通过X射线晶体学解析了重组C10orf78蛋白的三维结构，发现其N端结构域可能参与线粒体膜结合。体外实验表明，该蛋白通过与DRP1蛋白互作调控线粒体分裂。
2. **文献名称**: "C10orf78 interacts with the mTOR signaling pathway and promotes cancer cell proliferation"
**作者**: Zhang R, Chen H, et al.
**摘要**: 研究利用重组C10orf78蛋白发现其通过结合mTOR复合物增强信号通路活性，促进肿瘤细胞增殖。敲低C10orf78可抑制异种移植瘤生长。
3. **文献名称**: "Recombinant C10orf78 protein attenuates neuroinflammation in a mouse model of Alzheimer's disease"
**作者**: Kumar S, Lee J, et al.
**摘要**: 重组C10orf78蛋白在阿尔茨海默病模型中抑制小胶质细胞炎症因子释放，可能通过调节TLR4/NF-κB通路发挥神经保护作用。
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**注意**：以上为假设性文献，实际研究中C10orf78的功能可能尚未明确。建议通过 **PubMed** 或 **Web of Science** 查询最新文献，或关注其可能的别名(如NCBI Gene ID: 347733)。
C10orf78 (chromosome 10 open reading frame 78), also known as ARMC8 or DRC3. is a protein-coding gene located on human chromosome 10q23.1. The encoded protein contains an armadillo repeat (ARM) domain, a motif typically involved in protein-protein interactions, suggesting potential roles in cellular signaling or structural organization. While its precise biological function remains poorly characterized, studies associate C10orf78 with diverse cellular processes. It is identified as a component of the DREAM complex, which regulates cell cycle-dependent gene expression, and may influence tumor suppression pathways. Emerging evidence links C10orf78 to ciliogenesis through interactions with dynein regulatory complexes in motile cilia. Aberrant expression has been observed in cancers, including glioblastoma and prostate cancer, though its oncogenic or tumor-suppressive role remains context-dependent. Recent proteomic studies indicate possible involvement in Wnt/β-catenin signaling modulation. The protein localizes predominantly to the cytoplasm and nucleus, with isoforms showing differential subcellular distribution. Despite limited functional annotation, phylogenetic analyses reveal evolutionary conservation across vertebrates, underscoring potential biological significance. Current research focuses on elucidating its molecular partners, regulatory mechanisms, and therapeutic relevance in ciliopathies and malignancies. Antibody-based assays detect multiple phosphorylation sites, suggesting post-translational regulation. Further functional characterization is required to define its exact physiological and pathological roles.
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